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Titolo:
Dexfenfluramine-induced contraction of human and rat isolated pulmonary arteries
Autore:
Patnaude, LA; Undem, BJ; ORourke, ST;
Indirizzi:
N Dakota State Univ, Dept Pharmaceut Sci, Fargo, ND 58105 USA N Dakota State Univ Fargo ND USA 58105 harmaceut Sci, Fargo, ND 58105 USA Johns Hopkins Asthma & Allergy Ctr, Div Clin Immunol & Allergy, Baltimore,MD 21224 USA Johns Hopkins Asthma & Allergy Ctr Baltimore MD USA 21224 re,MD 21224 USA
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 2, volume: 401, anno: 2000,
pagine: 229 - 234
SICI:
0014-2999(20000804)401:2<229:DCOHAR>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYPERTENSION; FENFLURAMINE; VASOCONSTRICTION; DRUGS;
Keywords:
pulmonary arteries; dexfenfluramine; phentolamine; prazosin; ketanserin; indomethacin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: O'Rourke, ST N Dakota State Univ, Dept Pharmaceut Sci, Fargo, ND 58105 USAN Dakota State Univ Fargo ND USA 58105 , Fargo, ND 58105 USA
Citazione:
L.A. Patnaude et al., "Dexfenfluramine-induced contraction of human and rat isolated pulmonary arteries", EUR J PHARM, 401(2), 2000, pp. 229-234

Abstract

Mechanisms of dexfenfluramine-induced vasoconstriction were studied in isolated pulmonary arteries suspended in organ baths for isometric tension recording. Dexfenfluramine (10(-7)-10(-4) M) caused concentration-dependent contractions in rat and human pulmonary arteries with and without endothelium. In pulmonary arteries of the rat, the response to dexfenfluramine was nearly abolished by treatment with the cr-adrenoceptor antagonists, phentolamine (10(-6) M) or prazosin (10(-7) M). In human pulmonary arteries, the concentration-response curve to dexfenfluramine was unaltered by the presence of phentolamine (10(-6) M), prazosin (10(-7) M), ketanserin (10(-6) hi), or indomethacin (3 x 10(-6) M). The results suggest that dexfenfluramine causes contraction of pulmonary vascular smooth muscle by multiple mechanisms, one of which involves activation of a-adrenoceptors within the blood vessel wall. The mechanisms by which dexfenfluramine causes pulmonary vasoconstriction may differ between rat and human pulmonary arteries. (C) 2000 Published by Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 07:47:20