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Titolo:
Correlation between neuroleptic binding to sigma(1) and sigma(2) receptorsand acute dystonic reactions
Autore:
Matsumoto, RR; Pouw, B;
Indirizzi:
Univ Oklahoma, Hlth Sci Ctr, Coll Pharm, Dept Pharmaceut Sci, Oklahoma City, OK 73190 USA Univ Oklahoma Oklahoma City OK USA 73190 Sci, Oklahoma City, OK 73190 USA
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 2, volume: 401, anno: 2000,
pagine: 155 - 160
SICI:
0014-2999(20000804)401:2<155:CBNBTS>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
DRUG-INDUCED DYSTONIA; GUINEA-PIG BRAIN; SCHIZOPHRENIC-PATIENTS; AUTORADIOGRAPHIC VISUALIZATION; INTRAVENOUS METOCLOPRAMIDE; EXTRAPYRAMIDAL SYMPTOMS; ANTIPSYCHOTIC-DRUGS; RISK FACTOR; HALOPERIDOL; LIGANDS;
Keywords:
sigma receptor; neuroleptic; haloperidol; dystonia; extrapyramidal;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Matsumoto, RR Univ Oklahoma, Hlth Sci Ctr, Coll Pharm, Dept Pharmaceut Sci, POB 26901, Oklahoma City, OK 73190 USA Univ Oklahoma POB 26901 Oklahoma City OK USA 73190 73190 USA
Citazione:
R.R. Matsumoto e B. Pouw, "Correlation between neuroleptic binding to sigma(1) and sigma(2) receptorsand acute dystonic reactions", EUR J PHARM, 401(2), 2000, pp. 155-160

Abstract

Acute dystonic reactions are motor side effects that occur soon after the initiation of neuroleptic treatment. Although earlier studies indicate thatthese abnormal movements can be induced in animals and humans via activation of a receptors, the relative contribution of the different sigma receptor subtypes is unknown. Since sigma(1) and sigma(2) receptor are differentially represented in motor regions of the brain, the affinities, of 17 neuroleptics for these sigma receptor subtypes were determined using competition binding studies. The results revealed that most neuroleptics do not exhibitselectivity for either of the a receptor subtypes, as reflected by a significant correlation between the affinities of the neuroleptics for sigma(1) vs. sigma(2) receptors. Moreover, when the sigma binding affinities of the neuroleptics were correlated with the tendency of the drugs to produce acute dystonic reactions in humans, then was a significant correlation for bothsubtypes. Together with earlier studies in animals, the data suggest that neuroleptic-induced motor side effects can be mediated through both sigma(1) and sigma(2) receptors. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 19:19:32