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Titolo:
Lck is involved in interleukin-2-induced proliferation, but not cell survival, in human T cells through a MAP kinase-independent pathway
Autore:
Brockdorff, J; Nielsen, M; Kaltoft, K; Mustelin, T; Ropke, C; Svejgaard, A; Geisler, C; Odum, N;
Indirizzi:
Univ Copenhagen, Panum Inst, Inst Med Microbiol & Immunol, DK-2200 Copenhagen N, Denmark Univ Copenhagen Copenhagen Denmark N unol, DK-2200 Copenhagen N, Denmark Univ Aarhus, Inst Human Genet, DK-8000 Aarhus, Denmark Univ Aarhus Aarhus Denmark DK-8000 Human Genet, DK-8000 Aarhus, Denmark Burnham Inst, Lab Signal Transduct, La Jolla, CA 92037 USA Burnham Inst La Jolla CA USA 92037 gnal Transduct, La Jolla, CA 92037 USA Univ Copenhagen, Inst Med Anat, Sect A, DK-1168 Copenhagen, Denmark Univ Copenhagen Copenhagen Denmark DK-1168 , DK-1168 Copenhagen, Denmark Univ Copenhagen Hosp, Rigshosp, Dept Clin Immunol, DK-2100 Copenhagen, Denmark Univ Copenhagen Hosp Copenhagen Denmark DK-2100 2100 Copenhagen, Denmark
Titolo Testata:
EUROPEAN CYTOKINE NETWORK
fascicolo: 2, volume: 11, anno: 2000,
pagine: 225 - 231
SICI:
1148-5493(200006)11:2<225:LIIIIP>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR-BETA-CHAIN; SIGNAL-TRANSDUCTION; IL-2 RECEPTOR; TYROSINE PHOSPHORYLATION; LYMPHOCYTE-PROLIFERATION; C-MYC; ACTIVATION; PROTEIN; P56(LCK); GROWTH;
Keywords:
T lymphocytes; IL-2R; mycosis fungoides; PP1; Src kinases family; signaling;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Odum, N Univ Copenhagen, Panum Inst, Inst Med Microbiol & Immunol, Bldg 22-5,Blegdamsvej 3, DK-2200 Copenhagen N, Denmark Univ Copenhagen Bldg 22-5,Blegdamsvej 3 Copenhagen Denmark N mark
Citazione:
J. Brockdorff et al., "Lck is involved in interleukin-2-induced proliferation, but not cell survival, in human T cells through a MAP kinase-independent pathway", EUR CYTOKIN, 11(2), 2000, pp. 225-231

Abstract

The role of Lck in IL-2-induced proliferation and cell survival is still controversial. Here, we show that the Src family kinase inhibitor, PP1, reduced the IL-2-induced proliferation of human T cells significantly without inhibiting the anti-apoptotic effect of IL-2. As Lck is the only Src family kinase activated upon IL-2 stimulation in T cells, this indicates that Lck is involved in IL-2-induced proliferation but not survival. IL-2-induced MAP kinase activation was only slightly inhibited by PP1, suggesting that Lckis not essential for IL-2-induced MAP kinase activation in human T cells, We found that an IL-2-sensitive, human mycosis fungoides-derived tumor T cell line is Lck negative, and that the IL-2-induced MAP kinase activation iscomparable to non-cancerous T cells, although a little delayed in kinetics, An Lck expressing clone was established by transfecting Lck into mycosis fungoides tumor T cells, but Lck had no influence on the delayed kinetics of MAP kinase activation, indicating that Lck is not essential for MAP kinase activation in mycosis fungoides tumor T cells or in non-cancerous T cells. Taken together, this indicates that Lck is involved in IL-2-induced proliferation, but not cell survival, through a pathway not involving MAP kinase.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 07:57:14