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Titolo:
Pretreatment expression of the perforin gene by circulating CD8(+) T lymphocytes predicts biochemical response to interferon-alpha in patients with chronic hepatitis C
Autore:
Balian, A; Naveau, S; Zou, WP; Durand-Gasselin, I; Bouchet, L; Foussat, A; Galanaud, P; Chaput, JC; Emilie, D;
Indirizzi:
Hop Antoine Beclere, Serv Hepatogastroenterol, Inst Paris Sud Cytokines, F-92140 Clamart, France Hop Antoine Beclere Clamart France F-92140 ines, F-92140 Clamart, France Hop Antoine Beclere, INSERM, Inst Paris Sud Cytokines, U131, F-92140 Clamart, France Hop Antoine Beclere Clamart France F-92140 U131, F-92140 Clamart, France
Titolo Testata:
EUROPEAN CYTOKINE NETWORK
fascicolo: 2, volume: 11, anno: 2000,
pagine: 177 - 184
SICI:
1148-5493(200006)11:2<177:PEOTPG>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
VIRAL-HEPATITIS; VIRUS-INFECTION; CYTOTOXIC-CELLS; DEFICIENT MICE; IN-VIVO; RIBAVIRIN; THERAPY; ACTIVATION; INTERLEUKIN-12; COMBINATION;
Keywords:
perforin; hepatitis C; interferon-alpha; cytotoxic T lymphocyte;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Balian, A Hop Antoine Beclere, Serv Hepatogastroenterol, Inst Paris Sud Cytokines, 157 Rue Carnets, F-92140 Clamart, France Hop Antoine Beclere 157 Rue Carnets Clamart France F-92140 ance
Citazione:
A. Balian et al., "Pretreatment expression of the perforin gene by circulating CD8(+) T lymphocytes predicts biochemical response to interferon-alpha in patients with chronic hepatitis C", EUR CYTOKIN, 11(2), 2000, pp. 177-184

Abstract

It would be of great value to be able to predict, before the initiation oftreatment, which patients with hepatitis C virus-induced chronic hepatitiswill be cured by interferon-alpha (IFN-alpha), Competitive RT-PCR was usedto evaluate spontaneous expression of the perforin gene, a marker of cytotoxic cell activation, by circulating mononuclear cells in 17 patients undergoing IFN-alpha treatment, IFN-alpha increased perforin gene expression (p < 0.003), but this was not correlated with outcome. In contrast, pretreatment perforin gene expression levels were higher in the 8 patients with a sustained biochemical response after treatment than in the 9 non-responsive patients (p = 0.01). This factor predicted favorable clinical outcome with a sensitivity of 75% and a specificity of 89%, Thus, pretreatment immunological status has a major influence on the ability of IFN-alpha to cure chronichepatitis C, and the evaluation of perforin gene expression may help to select patients that will benefit from IFN-alpha treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 06:11:41