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Titolo:
Dopaminergic phenotype of hNT cells in vitro
Autore:
Zigova, T; Barroso, LF; Willing, AE; Saporta, S; McGrogan, MP; Freeman, TB; Sanberg, PR;
Indirizzi:
Univ S Florida, Coll Med, Dept Neurosurg, Tampa, FL 33612 USA Univ S Florida Tampa FL USA 33612 ed, Dept Neurosurg, Tampa, FL 33612 USA Univ S Florida, Coll Med, Dept Anat, Tampa, FL 33612 USA Univ S Florida Tampa FL USA 33612 oll Med, Dept Anat, Tampa, FL 33612 USA Univ S Florida, Coll Med, Neurosci Program, Tampa, FL 33612 USA Univ S Florida Tampa FL USA 33612 , Neurosci Program, Tampa, FL 33612 USA Layton BioSci Inc, Atherton, CA 94027 USA Layton BioSci Inc Atherton CA USA 94027 ioSci Inc, Atherton, CA 94027 USA
Titolo Testata:
DEVELOPMENTAL BRAIN RESEARCH
fascicolo: 1, volume: 122, anno: 2000,
pagine: 87 - 90
SICI:
0165-3806(20000730)122:1<87:DPOHCI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSPORTER MESSENGER-RNA; TYROSINE-HYDROXYLASE; ALDEHYDE DEHYDROGENASE; NEURONS; EXPRESSION; RECEPTORS; ASTROCYTES;
Keywords:
hNT neuron; tyrosine hydroxylase; dopamine transporter; dopamine receptor D2; aldehyde dehydrogenase; immunocytochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Zigova, T Univ S Florida, Coll Med, Dept Neurosurg, Tampa, FL 33612 USA Univ S Florida Tampa FL USA 33612 eurosurg, Tampa, FL 33612 USA
Citazione:
T. Zigova et al., "Dopaminergic phenotype of hNT cells in vitro", DEV BRAIN R, 122(1), 2000, pp. 87-90

Abstract

We investigated the catecholaminergic nature of cultured hNT neurons previously treated either for 4 or 5 weeks with retinoic acid (RA). There were significantly mon tyrosine hydroxylase (TH)-positive neurons (60%) in cultures treated for 4 weeks with RA compared to 5 week-treated cultures (less than or equal to 15%). Furthermore, numerous TH-positive hNT cells were also immunoreactive to dopamine transporter (DAT), dopamine receptor (D2) and aldehyde dehydrogenase (AHD-2), an enzyme exclusively expressed by dopaminergic (DA) ventral mesencephalic (VM) precursors. Thus this cell line has all the necessary cellular machinery to produce functional DA neurons and therefore is a good alternative tissue source to fetal VM. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:45:40