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Titolo:
Drugs with estrogen-like potency and brain activity: Potential therapeuticapplication for the CNS
Autore:
Cyr, M; Calon, F; Morissette, M; Grandbois, M; Callier, S; Di Paolo, T;
Indirizzi:
Univ Laval, Med Ctr CHUL, Oncol & Mol Endocrinol Res Ctr, Quebec City, PQ G1V 4G2, Canada Univ Laval Quebec City PQ Canada G1V 4G2 Quebec City, PQ G1V 4G2, Canada Univ Laval, Fac Pharm, Quebec City, PQ G1V 4G2, Canada Univ Laval Quebec City PQ Canada G1V 4G2 Quebec City, PQ G1V 4G2, Canada
Titolo Testata:
CURRENT PHARMACEUTICAL DESIGN
fascicolo: 12, volume: 6, anno: 2000,
pagine: 1287 - 1312
SICI:
1381-6128(200008)6:12<1287:DWEPAB>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA EXPRESSION; DEHYDROEPIANDROSTERONE-SULFATE DHEAS; MPTP-INDUCED NEUROTOXICITY; CENTRAL-NERVOUS-SYSTEM; FEMALE RAT-BRAIN; CHOLINE-ACETYLTRANSFERASE ACTIVITY; NIGROSTRIATAL DOPAMINERGIC SYSTEM; DORSOLATERAL PREFRONTAL CORTEX; DENDRITIC SPINE DENSITY; RECEPTOR-IMMUNOREACTIVE CELLS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
361
Recensione:
Indirizzi per estratti:
Indirizzo: Di Paolo, T Univ Laval, Med Ctr CHUL, Oncol & Mol Endocrinol Res Ctr, 2705Laurier Blvd, Quebec City, PQ G1V 4G2, Canada Univ Laval 2705 Laurier BlvdQuebec City PQ Canada G1V 4G2 ada
Citazione:
M. Cyr et al., "Drugs with estrogen-like potency and brain activity: Potential therapeuticapplication for the CNS", CUR PHARM D, 6(12), 2000, pp. 1287-1312

Abstract

Numerous reports, ranging from molecular investigations to clinical studies, demonstrate the potency of estrogens to modulate brain function and their implications in schizophrenia and depression. Alterations of dopaminergic, cholinergic, GABAergic, glutamatergic and serotonergic neurotransmission through estrogen-mediated mechanisms have been consistently established. Moreover, studies using in vivo and in vitro models as well as epidemiological data suggest that estrogens provide neuroprotection of central nervous system (CNS) cells implicated in the etiology of neurodegenerative disorders such as Alzheimer's (AD) and Parkinson's (PD) diseases. Numerous genomic ornon-genomic mechanisms of actions of estrogens in the brain have been documented implicating classical nuclear estrogen receptors as well as possibleestrogen membrane receptors, antioxidant activity of steroids, their effect on fluidity as well as on antiapoptotic proteins and growth factors. Selective estrogen receptor modulators (SERMs) have estrogenic and/or antiestrogenic activity depending on the target tissue. Hence, SERMs have the same beneficial effect as estrogen in skeleton and cardiovascular systems but actas antagonists in breast and uterus, The finding of beneficial side effects of SERMs in the CNS might improve their risk-benefit ratio in traditionalindications. In this review, we will survey schizophrenia and depression as examples of mental diseases and AD and PD as neurodegenerative diseases. We will review brain effects of estrogens, steroids possibly acting as pro-drugs of estrogens such as testosterone and dehydroepiandrosterone (DHEA) and present novel findings with SERMs. Drugs with estrogen activity in the brain may have therapeutic potential either by modulating brain neurotransmitter transmission or through neuroprotective activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/08/20 alle ore 17:07:47