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Titolo:
Salt intake and sensitivity of intestinal and renal Na+K+- ATPase to inhibition by dopamine in spontaneous hypertensive and Wistar-Kyoto rats
Autore:
Lucas-Teixeira, VA; Vieira-Coelho, MA; Serrao, P; Pestana, M; Soares-da-Silva, P;
Indirizzi:
Fac Med Porto, Inst Pharmacol & Therapeut, P-4200 Oporto, Portugal Fac MedPorto Oporto Portugal P-4200 Therapeut, P-4200 Oporto, Portugal
Titolo Testata:
CLINICAL AND EXPERIMENTAL HYPERTENSION
fascicolo: 5, volume: 22, anno: 2000,
pagine: 455 - 469
SICI:
1064-1963(200007)22:5<455:SIASOI>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
JEJUNAL ELECTROLYTE TRANSPORT; PROXIMAL CONVOLUTED TUBULE; K+-ATPASE; GASTROINTESTINAL-TRACT; GENETIC-HYPERTENSION; ADENYLATE-CYCLASE; SODIUM-EXCRETION; RECEPTOR; 5-HYDROXYTRYPTAMINE; ACTIVATION;
Keywords:
hypertension; sodium; dopamine; intestine; Na+,K+-ATPase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Lucas-Teixeira, VA Fac Med Porto, Inst Pharmacol & Therapeut, P-4200 Oporto, Portugal Fac Med Porto Oporto Portugal P-4200 Oporto, Portugal
Citazione:
V.A. Lucas-Teixeira et al., "Salt intake and sensitivity of intestinal and renal Na+K+- ATPase to inhibition by dopamine in spontaneous hypertensive and Wistar-Kyoto rats", CLIN EXP HY, 22(5), 2000, pp. 455-469

Abstract

The present study evaluated the activity of jejunal Na+-K+-ATPase and its sensitivity to inhibition by dopamine in spontaneous hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats during low (LS), normal (NS) and high (HS) salt intake. Basal jejunal Na+-K+-ATPase activity in SHR on LS intake was higher than in WKY rats. Jejunal Na+-K+-ATPase activity in WKY rats, but not in SHR, on LS intake was significantly reduced (20% decrease) by dopamine (1mu M) and SKF 38393 (10nM), but not quinerolane (10 nM), this being antagonized the D-1 receptor antagonist (SKF 83566). Changing from LS to NS or HSintake in WKY rats increased basal jejunal Na+-K+-ATPase activity and attenuated the inhibitory effect of dopamine. In SHR, changing from LS to NS orHS intake increased basal jejunal Na+-K+-ATPase activity. Basal renal Na+-K+-ATPase activity in SHR on LS intake was similar to that in WKY rats and was insensitive to inhibition by dopamine. Changing from LS to NS or HS intake in WKY rats increased basal renal Na+-K+-ATPase activity without affecting the inhibitory effect of-dopamine. In SHR, changing from LS to NS or HSintake failed to alter basal renal Na+-K+ AT-Pase activity. It is concluded that inhibition of jejunal Na+-K+ ATPase activity by D-1 dopamine receptor activation is dependent on salt intake in WKY rats, and SHR animals fail to respond to dopamine, irrespective of their salt intake.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 19:20:18