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Titolo:
Association of systolic blood pressure with macrovascular and microvascular complications of type 2 diabetes (UKPDS 36): prospective observational study
Autore:
Adler, AI; Stratton, IM; Neil, HAW; Yudkin, JS; Matthews, DR; Cull, CA; Wright, AD; Turner, RC; Holman, RR;
Indirizzi:
Univ Oxford, Radcliffe Infirm, Oxford Ctr Diabet Endocrinol & Metab, Diabet Trial Unit, Oxford OX2 6HE, England Univ Oxford Oxford England OX2 6HE t Trial Unit, Oxford OX2 6HE, England Univ Oxford, Inst Hlth Sci, Div Publ Hlth & Primary Care, Oxford OX3 7LF, England Univ Oxford Oxford England OX3 7LF Primary Care, Oxford OX3 7LF, England Univ Coll London, Sch Med, Whittington Hosp, London N19 3UA, England Univ Coll London London England N19 3UA on Hosp, London N19 3UA, England Selly Oak Hosp, Birmingham B29 6JD, W Midlands, England Selly Oak Hosp Birmingham W Midlands England B29 6JD W Midlands, England Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Diabet Res Labs, OxfordOX2 6HE, England Univ Oxford Oxford England OX2 6HE abet Res Labs, OxfordOX2 6HE, England
Titolo Testata:
BRITISH MEDICAL JOURNAL
fascicolo: 7258, volume: 321, anno: 2000,
pagine: 412 - 419
SICI:
0959-8138(20000812)321:7258<412:AOSBPW>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; MIDDLE-AGED PATIENTS; RISK-FACTORS; CARDIOVASCULAR MORTALITY; FOLLOW-UP; MYOCARDIAL-INFARCTION; STROKE; MEN; HYPERTENSION; MELLITUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Adler, AI Univ Oxford, Radcliffe Infirm, Oxford Ctr Diabet Endocrinol & Metab, Diabet Trial Unit, Oxford OX2 6HE, England Univ Oxford Oxford England OX2 6HE it, Oxford OX2 6HE, England
Citazione:
A.I. Adler et al., "Association of systolic blood pressure with macrovascular and microvascular complications of type 2 diabetes (UKPDS 36): prospective observational study", BR MED J, 321(7258), 2000, pp. 412-419

Abstract

Objective To determine the relation between systolic blood pressure over time and the risk of macrovascular or microvascular complications in patients dth type 2 diabetes. Design Prospective observational study. Setting 23 hospital based clinics in England, Scotland and Northern Ireland Participants 4801 white, Asian Indian, and Afro-Caribbean UKPDS patients,whether randomised or not to treatment, were included in analyses of incidence; of these, 3642 were included in analyses of relative risk,Outcome measures Primary predefined aggregate clinical outcomes: any complications or deaths related to diabetes and all cause mortality. Secondary aggregate outcomes: myocardial infarction, stroke, lower extremity amputation (including death from peripheral vascular disease), and microvascular disease (predominantly retinal photocoagulation). Single end points: non-fatalheart failure and cataract extraction Risk reduction associated with a 10 mm Hg decrease in updated mean systolic blood pressure adjusted for specific confoundersResults The incidence of clinical complications was significantly associated with systolic blood pressure, except for cataract extraction. Each 10 mmHg decrease in updated mean systolic blood pressure was associated with reductions in risk of 12% for any complication related to diabetes (95%, confidence interval 10% to 14%, P < 0.0001), 15% for deaths related to diabetes(12% to 18%, P< 0.0001), 11% for myocardial infarction (7% to 14%, P< 0.0001), and 13% for microvascular complications (10% to 16%, P< 0.0001). No threshold of risk was observed for any end point. Conclusions In patients with type 2 diabetes the risk of diabetic complications was strongly associated with raised blood pressure. Any reduction in blood pressure is likely to reduce the risk of complications, with the lowest risk being in those with systolic blood pressure less than 120 mm Hg.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 00:35:31