Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study
Autore:
Stratton, IM; Adler, AI; Neil, HAW; Matthews, DR; Manley, SE; Cull, CA; Hadden, D; Turner, RC; Holman, RR;
Indirizzi:
Univ Oxford, Radcliffe Infirm, Oxford Ctr Diabet Endocrinol & Metab, Diabet Trials Unit, Oxford OX2 6HE, England Univ Oxford Oxford England OX2 6HE Trials Unit, Oxford OX2 6HE, England Univ Oxford, Inst Hlth Sci, Div Publ Hlth & Primary Care, Oxford OX3 7LF, England Univ Oxford Oxford England OX3 7LF Primary Care, Oxford OX3 7LF, England Royal Victoria Hosp, Belfast BT12 6BA, Antrim, North Ireland Royal Victoria Hosp Belfast Antrim North Ireland BT12 6BA , North Ireland Univ Oxford, Radcliffe Infirm, Oxford Ctr Diabet Endocrinol & Metab, Diabet Res Labs, Oxford OX2 6HE, England Univ Oxford Oxford England OX2 6HE bet Res Labs, Oxford OX2 6HE, England
Titolo Testata:
BRITISH MEDICAL JOURNAL
fascicolo: 7258, volume: 321, anno: 2000,
pagine: 405 - 412
SICI:
0959-8138(20000812)321:7258<405:AOGWMA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; RISK-FACTORS; CARDIOVASCULAR MORTALITY; SENSORY NEUROPATHY; GLYCEMIC THRESHOLD; FOLLOW-UP; MELLITUS; NIDDM; GLUCOSE; STROKE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Stratton, IM Univ Oxford, Radcliffe Infirm, Oxford Ctr Diabet Endocrinol &Metab, Diabet Trials Unit, Oxford OX2 6HE, England Univ Oxford Oxford England OX2 6HE Oxford OX2 6HE, England
Citazione:
I.M. Stratton et al., "Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study", BR MED J, 321(7258), 2000, pp. 405-412

Abstract

Objective To determine the relation between exposure to glycaemia over time and the risk of macro vascular or microvascular complications in patientswith type 2 diabetes. Design Prospective observational study. Setting 23 hospital based clinics in England, Scotland, and Northern ireland. Participants 4585 white, Asian Indian, and Afro-Caribbean UKPDS patients, whether randomised or not to treatment, were included in analyses of incidence; of these, 3642 were included in analyses of relative risk. Outcome measures Primary predefined aggregate clinical outcomes: any end point or deaths related to diabetes and all cause mortality. Secondary aggregate outcomes: myocardial infarction, stroke, amputation (including death from peripheral vascular disease), and microvascular disease (predominantly retinal photocoagulation). Single end points: non-fatal heart failure and cataract extraction. Risk reduction associated with a 1% reduction in updated mean HbA(1c) adjusted for possible confounders at diagnosis of diabetes. Results The incidence of clinical complications was significantly associated with glycaemia. Each 1% reduction in updated mean HbA(1c) was associatedwith reductions in risk of 21% for any end point related to diabetes (95% confidence interval 17% to 24%, P < 0.0001), 21% for deaths related to diabetes (15% to 27%, P < 0.0001), 14% for myocardial infarction (8% to 21%, P<0.0001), and 37% for microvascular complications (33% to 41%, P < 0.0001). No threshold of risk was observed for any end pointConclusions Ln patients with type 2 diabetes the risk of diabetic complications was strongly associated with previous hyperglycaemia. Any reduction in HbA(1c) is likely to reduce the risk of complications, with the lowest risk being in those with HbA(1c) values in the normal range (< 6.0%).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 22:22:18