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Titolo:
Effects of exercise on lymphocytes and cytokines
Autore:
Pedersen, BK; Toft, AD;
Indirizzi:
Univ Copenhagen, Rigshosp, Dept Infect Dis M7721, DK-2200 Copenhagen N, Denmark Univ Copenhagen Copenhagen Denmark N 7721, DK-2200 Copenhagen N, Denmark Univ Copenhagen, Rigshosp, Copenhagen Muscle Res Ctr, DK-2200 Copenhagen, Denmark Univ Copenhagen Copenhagen Denmark DK-2200 , DK-2200 Copenhagen, Denmark
Titolo Testata:
BRITISH JOURNAL OF SPORTS MEDICINE
fascicolo: 4, volume: 34, anno: 2000,
pagine: 246 - 251
SICI:
0306-3674(200008)34:4<246:EOEOLA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYUNSATURATED FATTY-ACIDS; TUMOR-NECROSIS-FACTOR; KILLER-CELL-ACTIVITY; RESPIRATORY-TRACT INFECTION; VITAMIN-C SUPPLEMENTATION; IMMUNE-SYSTEM; PHYSICAL-ACTIVITY; DIETARY SUPPLEMENTATION; PERITONEAL-MACROPHAGES; PERIPHERAL-BLOOD;
Keywords:
exercise; cytokine; lymphocytes; immunosuppression; nutrition;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Pedersen, BK Univ Copenhagen, Rigshosp, Dept Infect Dis M7721, Tagensvej 20, DK-2200 Copenhagen N, Denmark Univ Copenhagen Tagensvej 20 Copenhagen Denmark N N, Denmark
Citazione:
B.K. Pedersen e A.D. Toft, "Effects of exercise on lymphocytes and cytokines", BR J SP MED, 34(4), 2000, pp. 246-251

Abstract

Objectives-To review results on exercise induced changes in the immune system following strenuous and moderate exercise. Methods-A literature search over the past IS years was conducted using Medline and selected papers. Results-After intense long term exercise, the immune system is characterised by concomitant impairment of the cellular immune system and increased inflammation. Thus low concentrations of lymphocytes, suppressed natural immunity, suppressed lymphocyte proliferation, and suppressed levels of secretory IgA in saliva are found simultaneously with high levels of circulating proinflammatory and anti-inflammatory cytokines. The underlying mechanisms are multifactorial and include neuroendocrinological and metabolic factors. The clinical consequences of the exercise induced immune changes have not formally been identified, but the exercise effect on lymphocyte dynamics andimmune function may be linked to the exercise effects on resistance to infections and malignancy and the cytokine response maybe linked to muscle damage or muscle cell growth. Conclusions-Moderate exercise across the life span seems to increase resistance to upper respiratory tract infections, whereas repeated strenuous exercise suppresses immune function. It is premature to offer advice on nutrition to athletes in order to alter the exercise induced immunosuppression found after exercise.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:44:13