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Titolo:
Metabotropic glutamate receptor subtypes are differentially expressed after transient cerebral ischemia without, during and after tolerance inductionin the gerbil hippocampus
Autore:
Sommer, C; Roth, SU; Kuhn, R; Kiessling, M;
Indirizzi:
Univ Heidelberg, Dept Neuropathol, D-69120 Heidelberg, Germany Univ Heidelberg Heidelberg Germany D-69120 , D-69120 Heidelberg, Germany Nervous Syst Res, Basel, Switzerland Nervous Syst Res Basel SwitzerlandNervous Syst Res, Basel, Switzerland
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 872, anno: 2000,
pagine: 172 - 180
SICI:
0006-8993(20000728)872:1-2<172:MGRSAD>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
MGLUR1 SPLICE VARIANTS; DELAYED NEURONAL DEATH; GLOBAL-ISCHEMIA; RAT HIPPOCAMPUS; PROTEIN-SYNTHESIS; TEMPORAL PROFILE; MESSENGER-RNA; CA1 NEURONS; DEVELOPMENTAL EXPRESSION; NEUROLOGICAL DISORDERS;
Keywords:
gerbil; global ischemia; hippocampus; immunohistochemistry; metabotropic glutamate receptors; preconditioning;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Sommer, C Univ Heidelberg, Dept Neuropathol, Neuenheimer Feld 220, D-69120Heidelberg, Germany Univ Heidelberg Neuenheimer Feld 220 Heidelberg Germany D-69120
Citazione:
C. Sommer et al., "Metabotropic glutamate receptor subtypes are differentially expressed after transient cerebral ischemia without, during and after tolerance inductionin the gerbil hippocampus", BRAIN RES, 872(1-2), 2000, pp. 172-180

Abstract

Postischemic delayed neuronal death (DND) of hippocampal CA1 neurons can be prevented by a preconditioning sublethal ischemic stimulus. To check for possible participation of metabotropic glutamate receptors (mGluRs) in neuronal death or survival, we analyzed postischemic protein expression of subtypes 1b and 5 of group I mGluRs, which are thought to exert neurotoxic effects after pathological activation due to ischemia, and subtypes 2 and 3 of group II mGluRs, which in contrast are thought to be neuroprotective in this state, respectively. Therefore, three groups of gerbils with reperfusion intervals between 8 h and 4 days (n=5 each) were investigated: one roup wassubjected to 5 min ischemia, resulting in DND of CA1 neurons, a second group to a tolerance inducing 2.5 min period of ischemia and a third group to 5 min ischemia after prior tolerance induction. The major finding was a transient postischemic reduction of mGluR1b and 5 expression in the ischemic tolerant CA1 subfield at 8 h. This downregulation of neurotoxic mGluRs may indicate a contribution to the survival of highly vulnerable CA1 neurons in the ischemic tolerant state. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/01/20 alle ore 19:08:54