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Titolo:
Distributed neurodegenerative changes 2-28 days after ventral hippocampal excitotoxic lesions in rats
Autore:
Halim, ND; Swerdlow, NR;
Indirizzi:
Univ Calif San Diego, Sch Med, Dept Psychiat, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 ychiat, La Jolla, CA 92093 USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1, volume: 873, anno: 2000,
pagine: 60 - 74
SICI:
0006-8993(20000804)873:1<60:DNC2DA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPAMINE-GLUTAMATE INTERACTIONS; ACOUSTIC STARTLE REFLEX; PREPULSE INHIBITION; NUCLEUS-ACCUMBENS; PREFRONTAL CORTEX; SCHIZOPHRENIC-PATIENTS; ANIMAL-MODEL; GATING DEFICITS; SENSORIMOTOR; HABITUATION;
Keywords:
dopamine; hippocampus; ibotenic acid; nucleus accumbens; orbital cortex; prepulse inhibition; schizophrenia; silver stain; tyrosine hydroxylase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Swerdlow, NR Univ Calif San Diego, Sch Med, Dept Psychiat, 9500 Gillman Dr, La Jolla, CA 92093 USA Univ Calif San Diego 9500 Gillman Dr La Jolla CA USA 92093 SA
Citazione:
N.D. Halim e N.R. Swerdlow, "Distributed neurodegenerative changes 2-28 days after ventral hippocampal excitotoxic lesions in rats", BRAIN RES, 873(1), 2000, pp. 60-74

Abstract

An enhanced sensitivity to the behavioral effects of dopamine (DA) agonists in adult rats occurs after cytotoxic lesions of the ventral hippocampus (VHPC). While some of these behavioral changes may model specific abnormalities in schizophrenia patients, little is known shout the cellular events that underlie VHPC lesion-induced behavioral DA 'supersensitivity'. Neuropathological consequences of excitotoxin lesions of the VHPC were investigated in this study. Adult male rats received vehicle or ibotenic acid infusions into the VHPC, using parameters that produce an enhanced sensitivity to theprepulse inhibition-disruptive effects of the DA agonist apomorphine, 1 month post-lesion. A total of 27 rats were sacrificed, 2, 7, 14, 21 or 28 days post-lesion. Amino-cupric-silver staining demonstrated degenerative changes throughout the hippocampus, and in hippocampal efferent projections to forebrain structures, including the septal nucleus and nucleus accumbens (NAC), and within the olfactory tubercle (OT) and orbital cortex. Silver-impregnated fibers were identified in the substantia nigra reticulata (SNr), NAG, OT, septum and orbital cortex. Some degenerative changes were noted at the earliest time point (2 days post-lesion), while others were delayed in appearance. Adjacent sections stained for tyrosine hydroxylase (TH) immunocytochemistry revealed reduced TK labeling through forebrain DA terminal fields 28 days, but not 14 days after VH lesions. Excitotoxic lesions of the VHPC result in distributed neurotoxic changes in subcortical and cortical brain regions; these changes may contribute to the delayed emergence of DA-mediated behavioral abnormalities in these animals. (C) 2000 Elsevier Science BSI. All rights reserved.

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Documento generato il 26/01/20 alle ore 00:55:35