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Titolo:
Possible association between serotonin transporter gene polymorphism and violent suicidal behavior in mood disorders
Autore:
Bellivier, F; Szoke, A; Henry, C; Lacoste, J; Bottos, C; Nosten-Bertrand, M; Hardy, P; Rouillon, F; Launay, JM; Laplanche, JL; Leboyer, M;
Indirizzi:
Hop Henri Mondor, Serv Psychiat Adulte, F-94010 Creteil, France Hop Henri Mondor Creteil France F-94010 Adulte, F-94010 Creteil, France Assistance Publ Hop Paris, Creteil, France Assistance Publ Hop Paris Creteil France ubl Hop Paris, Creteil, France Hop Charles Perrens, Serv Psychiat Adulte, Bordeaux, France Hop Charles Perrens Bordeaux France v Psychiat Adulte, Bordeaux, France Hop Lariboisiere, Assistance Publ Hop Paris, Lab Cent Biochim & Biol Mol, F-75475 Paris, France Hop Lariboisiere Paris France F-75475 & Biol Mol, F-75475 Paris, France Fac Med Creteil, INSERM U513, Unite Neurobiol & Psychiat, Creteil, France Fac Med Creteil Creteil France te Neurobiol & Psychiat, Creteil, France Hop Bicetre, Assistance Publ Hop Paris, Le Kremlin Bicetre, France Hop Bicetre Le Kremlin Bicetre France Paris, Le Kremlin Bicetre, France
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 4, volume: 48, anno: 2000,
pagine: 319 - 322
SICI:
0006-3223(20000815)48:4<319:PABSTG>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUSCEPTIBILITY; DEPRESSION; UNIPOLAR; PROMOTER; BIPOLAR; FAMILY;
Keywords:
serotonin transporter gene; affective disorder; suicidal behavior; candidate symptoms;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Bellivier, F Hop Henri Mondor, Serv Psychiat Adulte, 51 Ave Mal Lattre de Tassigny, F-94010 Creteil, France Hop Henri Mondor 51 Ave Mal Lattre de Tassigny Creteil France F-94010
Citazione:
F. Bellivier et al., "Possible association between serotonin transporter gene polymorphism and violent suicidal behavior in mood disorders", BIOL PSYCHI, 48(4), 2000, pp. 319-322

Abstract

Background: Genes involved in the serotonin system are major candidates inassociation studies of suicidal behavior. In this case-control study we investigated whether the serotonin transporter (5-HTT) gene encoding the protein responsible for the reuptake of serotonin from the synapse after its release from serotonergic neurons is a susceptibility factor for suicidal behaviorMethods: A functional polymorphism of the 5-HTT gene (a 44-base pair insertion/deletion in the 5-HTT-linked polymorphic region [5-HTTLPR]) was studied in a population of 237 consecutive patients with affective disorder (unipolar or bipolar) and 187 control subjects. Ninety-nine patients had attempted suicide at feast once, of whom 26 made a violent attempt. Results: No association was found between the "s" allele of the 5-HTTLPR and suicide attempt; however, there was a significant difference in allele distributions between patients who had made violent suicide attempts and control subjects. Conclusions: A generic variant of the 5-HTT gene may predispose individuals to violent suicidal behavior. The precise phenotype associated with the 5-HTT gene is unclear, and therefore further studies are required to replicate these findings. (C) 2000 Society of Biological Psychiatry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 15:48:19