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Titolo:
Serotonin transporter gene polymorphisms, alcoholism, and suicidal behavior
Autore:
Gorwood, P; Batel, P; Ades, J; Hamon, M; Boni, C;
Indirizzi:
CHU Louis Mourier, CNRS UMR 7593, Psychiat Serv, F-92700 Colombes, France CHU Louis Mourier Colombes France F-92700 Serv, F-92700 Colombes, France CHU Pitie Salpetriere, CNRS UMR 7593 Paris 07, Paris, France CHU Pitie Salpetriere Paris France NRS UMR 7593 Paris 07, Paris, France UTAMA, Hop Beaujon, Clichy, France UTAMA Clichy FranceUTAMA, Hop Beaujon, Clichy, France CHU Pitie Salpetriere, INSERM U288, Paris, France CHU Pitie Salpetriere Paris France petriere, INSERM U288, Paris, France
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 4, volume: 48, anno: 2000,
pagine: 259 - 264
SICI:
0006-3223(20000815)48:4<259:STGPAA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIPOLAR AFFECTIVE-DISORDER; REGULATORY REGION POLYMORPHISM; ANXIETY-RELATED TRAITS; FUNCTIONAL POLYMORPHISM; TRYPTOPHAN DEPLETION; CEREBROSPINAL-FLUID; ASSOCIATION; DEPRESSION; DEPENDENCE; ABUSE;
Keywords:
suicide; serotonin; genetics; behavior; impulsivity; addiction; dependence;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Gorwood, P CHU Louis Mourier, CNRS UMR 7593, Psychiat Serv, 178 Rue Renouillers, F-92700 Colombes, France CHU Louis Mourier 178 Rue Renouillers Colombes France F-92700
Citazione:
P. Gorwood et al., "Serotonin transporter gene polymorphisms, alcoholism, and suicidal behavior", BIOL PSYCHI, 48(4), 2000, pp. 259-264

Abstract

Background: Dysfunction of serotoninergic transmission could predispose toexcessive alcohol consumption and dependence, The functional polymorphism of the serotonin transporter gene (5-HTTLPR) has been associated with different disorders, including alcoholism Considering the likelihood of heterogeneity in the "alcohol dependence" phenotype, 5-HTTLPR may be more specifically implicated in subsamples of patients or in related traits of alcoholism, such as impulsivity,Methods: We analyzed the role of this functional polymorphism in the risk for suicide attempt in a population of male alcohol-dependent subjects. Onehundred ten male alcohol-dependent patients (DSM-III-R criteria), French for at least two generations, were personally interviewed with the Diagnostic Interview for Generic Studies and compared with 61 unaffected blood donors. Results: The "short" (S) allele of the 5-HTTLPR appeared to be unrelated to alcohol dependence and comorbid depression in our sample, bur was found associated with an increased risk for suicide attempts. This association waspredominantly observed in severe and repetitive suicide attempts, with a significant dose effect of the S allele (0, 1, or 2) on the number and the severity of suicide attempts. Conclusions: Mood disorders and alcohol dependence may interact with a genetic (relative) deficiency in serotonin reuptake, thereby increasing the risk for aggressive/impulsive behaviors such as suicide attempts. (C) 2000 Society of Biological Psychiatry.

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Documento generato il 02/04/20 alle ore 11:51:00