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Titolo:
Counteractive beta-adrenergic and endothelin subtype-ETB receptor signalling modulate proliferation in monkey renal cells (MRC)
Autore:
Drimal, J; Bauerova, K; Knezl, V; Kettmann, V;
Indirizzi:
Slovak Acad Sci, Inst Expt Pharmacol, SK-84216 Bratislava, Slovakia SlovakAcad Sci Bratislava Slovakia SK-84216 -84216 Bratislava, Slovakia
Titolo Testata:
BIOLOGIA
fascicolo: 3, volume: 55, anno: 2000,
pagine: 299 - 303
SICI:
0006-3088(200006)55:3<299:CBAESR>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; DHP BINDING-SITES; (-)--AZIDOPINE; IRL-1620; AGONIST;
Keywords:
endothelin-1; ETB receptors; down-regulation; proliferation; cyclic nucleotides; monkey renal cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Drimal, J Slovak Acad Sci, Inst Expt Pharmacol, Dubravska 9, SK-84216 Bratislava, Slovakia Slovak Acad Sci Dubravska 9 Bratislava Slovakia SK-84216 ovakia
Citazione:
J. Drimal et al., "Counteractive beta-adrenergic and endothelin subtype-ETB receptor signalling modulate proliferation in monkey renal cells (MRC)", BIOLOGIA, 55(3), 2000, pp. 299-303

Abstract

The purpose of this study was to establish whether cross-regulatory signalling from membrane- bound beta-adrenergic and endothelin receptors may modulate specific subtype-ETB receptor down-regulation and proliferation in cultured MRC. To determine whether these changes could lead to ETB receptor down-regulation, isoproterenol (IPN), immobilized IPN-copolymer (IPN-CP), photolabile, caged cyclic nucleotides (Caged-cAMP and Caged-cGMP) and two endothelin agonists (ET-1 and synthetic, truncated (8-21)ET-1 derivative) were used in the present study to stimulate cells. The ETB selective ligand [I-125]IRL-1620 in equilibrium-binding, [H-3]thymidine in incorporation experiments, cyclic nucleotides (cAMP and cGhIP) and endothelin RIA assays in MRC were used to characterize the major component of beta-adrenergic and endothelin signalling, subtype ETB receptor regulation and proliferation response. The results obtained in this study document beta-adrenergic, cyclic AMP mediated inhibition of proliferation and ETB selective down-regulation of surface-membrane endothelin receptors in stimulated cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 11:19:07