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Titolo:
D-methionine attenuates inner hair cell loss in carboplatin-treated chinchillas
Autore:
Lockwood, DS; Ding, DL; Wang, J; Salvi, RJ;
Indirizzi:
SUNY Buffalo, Hearing Res Lab, Ctr Hearing & Deafness, Buffalo, NY 14214 USA SUNY Buffalo Buffalo NY USA 14214 aring & Deafness, Buffalo, NY 14214 USA
Titolo Testata:
AUDIOLOGY AND NEURO-OTOLOGY
fascicolo: 5, volume: 5, anno: 2000,
pagine: 263 - 266
SICI:
1420-3030(200009/10)5:5<263:DAIHCL>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRODUCT OTOACOUSTIC EMISSIONS; EVOKED-POTENTIAL THRESHOLDS; CISPLATIN OTOTOXICITY; ANTIOXIDANT SYSTEM; SODIUM THIOSULFATE; HEARING-LOSS; PHASE-I; PROTECTION; NEPHROTOXICITY; CHEMOTHERAPY;
Keywords:
chinchilla; carboplatin; D-methionine; hair cells; ototoxicity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Salvi, RJ SUNY Buffalo, Hearing Res Lab, Ctr Hearing & Deafness, 215 Parker Hall, Buffalo, NY 14214 USA SUNY Buffalo 215 Parker Hall Buffalo NY USA 14214 , NY 14214 USA
Citazione:
D.S. Lockwood et al., "D-methionine attenuates inner hair cell loss in carboplatin-treated chinchillas", AUDIOL NEUR, 5(5), 2000, pp. 263-266

Abstract

Carboplatin, a second-generation platinum-based antineoplastic drug, preferentially destroys inner hair cells (IHCs) in the chinchilla while sparing outer hair cells (OHCs), D-Methionine (D-Met), a sulfur-containing amino acid, has been shown to protect hair cells from cisplatin damage in rats, butits ability to protect IHCs from carboplatin damage has not yet been evaluated in the chinchilla, We tested whether D-Met would protect the hair cells in the chinchilla from carboplatin, Animals were divided into two groups:a control group that only received carboplatin (100 mg/kg, i.p.) and an experimental group that received 300 mg/kg D-Met (i.p.) 30 min before carboplatin treatment. Ototoxicity was assessed by measuring the amount of IHC andOHC loss. Average IHC loss in the group treated with D-Met was 62% compared with 84% in the untreated control group. Thus, D-Met causes a statistically significant reduction in IHC loss induced by carboplatin. Copyright (C) 2000 S. Karger AG. Basel.

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Documento generato il 02/04/20 alle ore 18:50:19