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Titolo:
Development of chondroitin sulfate proteoglycans in the central auditory system of rats correlates with acquisition of mature properties
Autore:
Friauf, E;
Indirizzi:
Univ Frankfurt Klinikum, Zentrum Physiol, Inst Sinnes & Neurophysiol, D-60590 Frankfurt, Germany Univ Frankfurt Klinikum Frankfurt Germany D-60590 590 Frankfurt, Germany
Titolo Testata:
AUDIOLOGY AND NEURO-OTOLOGY
fascicolo: 5, volume: 5, anno: 2000,
pagine: 251 - 262
SICI:
1420-3030(200009/10)5:5<251:DOCSPI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUPERIOR OLIVARY NUCLEI; EXTRACELLULAR-MATRIX; NEURITE OUTGROWTH; POSTNATAL-DEVELOPMENT; PERINEURONAL NETS; COCHLEAR NUCLEUS; IMMUNOHISTOCHEMICAL LOCALIZATION; INFERIOR COLLICULUS; NEOCORTICAL NEURONS; ADHESION MOLECULES;
Keywords:
extracellular matrix; cochlear nuclear complex; superior olivary complex; lateral lemniscus; inferior colliculus; auditory cortex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Friauf, E Univ Kaiserslautern, Abt Tierphysiol, Postfach 3049, D-67653 Kaiserslautern, Germany Univ Kaiserslautern Postfach 3049 Kaiserslautern Germany D-67653
Citazione:
E. Friauf, "Development of chondroitin sulfate proteoglycans in the central auditory system of rats correlates with acquisition of mature properties", AUDIOL NEUR, 5(5), 2000, pp. 251-262

Abstract

Chondroitin sulfate proteoglycans (CSPGs) are macromolecules which regulate the structural organization of the extracellular matrix and can mediate cell migration and axonal growth. Here the spatiotemporal distribution of CSPGs in the central auditory system of rats was investigated using a polyclonal antiserum, in adult brains, CSPGs surrounded many neuronal cell bodies and proximal dendrites at all stations of the auditory pathway except the medial geniculate body. During development, CSPG expression became visible at postnatal day (P) 4 in the superior olivary complex, at P8 in the midbrain, and at P18 in the cortex. Immunoreactivity increased strongly until P12 in the brainstem and until P24 in the cortex. The adult-like pattern in thepontine nuclei, the midbrain, and the cortex was seen at P12, P29, and P35, respectively. The relatively late expression of strong immunoreactivity indicates that the CSPGs are involved in the maturation of axonal connections, but not in early processes such as cell migration or neurite outgrowth. Copyright (C) 2000 S. Karger AG. Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 11:10:11