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Titolo:
Nuclear localization of E-cadherin expression in Merkel cell carcinoma
Autore:
Han, AC; Soler, AP; Tang, CK; Knudsen, KA; Salazar, H;
Indirizzi:
Reading Hosp, Dept Pathol, Reading, PA 19612 USA Reading Hosp Reading PA USA 19612 osp, Dept Pathol, Reading, PA 19612 USA Med Ctr, Reading, PA 19612 USA Med Ctr Reading PA USA 19612Med Ctr, Reading, PA 19612 USA Lankenau Med Res Ctr, Wynnewood, PA USA Lankenau Med Res Ctr Wynnewood PAUSA nau Med Res Ctr, Wynnewood, PA USA Temple Univ Hosp, Dept Pathol, Philadelphia, PA 19140 USA Temple Univ Hosp Philadelphia PA USA 19140 ol, Philadelphia, PA 19140 USA
Titolo Testata:
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
fascicolo: 8, volume: 124, anno: 2000,
pagine: 1147 - 1151
SICI:
0003-9985(200008)124:8<1147:NLOEEI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-CATENIN; ADHESION MOLECULES; P-CADHERIN; N-CADHERIN; DIFFERENTIAL EXPRESSION; PLEURAL MESOTHELIOMAS; LUNG ADENOCARCINOMAS; TRABECULAR CARCINOMA; BREAST-CARCINOMA; CANCER-CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Han, AC Reading Hosp, Dept Pathol, 6th Ave & Spruce St, Reading, PA 19612 USA Reading Hosp 6th Ave & Spruce St Reading PA USA 19612 PA 19612 USA
Citazione:
A.C. Han et al., "Nuclear localization of E-cadherin expression in Merkel cell carcinoma", ARCH PATH L, 124(8), 2000, pp. 1147-1151

Abstract

Context-Cadherins are cell-cell adhesion proteins that act as tumor suppressor genes and have a critical role in cell sorting and tissue formation during organogenesis. The pattern of cadherin expression constitutes a usefuldiagnostic and prognostic tool in the evaluation of tumors and for determining the histogenesis of tumor cells. We have previously characterized the cell types of several tumors based on the expression of individual cadherins. Objective.-To investigate the expression of cadherins in Merkel cell carcinomas. Design.-Paraffin immunohistochemical analysis of the 3 best-studied cadherins was performed on 35 cases of Merkel cell carcinoma. Results.-E-cadherin was expressed in 34 (97%) of 35 Merkel cell carcinomasexamined, N-cadherin was expressed in 22 (63%) of 35 cases, and P-cadherinwas expressed in 15 (43%) of 35 cases. This frequency of cadherin expression was similar to a group of smalt cell and neuroendocrine tumors from other primary sites. Interestingly, the localization of E-cadherin expression was unique in Merkel cell carcinomas compared with other primary neuroendocrine tumors. Merkel cell carcinomas showed marked preference for nuclear versus membrane localization, whereas small cell tumors from other sites showed fewer cases of nuclear E-cadherin expression. The nuclear localization ofE-cadherin did not correlate with cadherin-associated protein beta-cateninnuclear expression. Conclusions.-Our findings show that E-cadherin is the most frequently expressed cadherin in Merkel cell carcinoma, followed in frequency by N-cadherin then P-cadherin. The pattern of nuclear E-cadherin expression is more frequent for Merkel cell carcinoma than smalt cell tumors of other primary sites. These observations suggest that E-cadherin expression and function are altered in Merkel cell carcinoma, and this finding has potential use in thedifferential diagnosis of these tumors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 20:07:17