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Titolo:
Temporolimbic volume reductions in schizophrenia
Autore:
Gur, RE; Turetsky, BI; Cowell, PE; Finkelman, C; Maany, V; Grossman, RI; Arnold, SE; Bilker, WB; Gur, RC;
Indirizzi:
Univ Penn, Sch Med, Dept Psychiat, Neuropsychiat Sect,Schizophrenia Res Ctr, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 a Res Ctr, Philadelphia, PA 19104 USA Univ Penn, Sch Med, Dept Radiol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 pt Radiol, Philadelphia, PA 19104 USA Univ Penn, Sch Med, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Epidemiol, Philadelphia, PA 19104 USA
Titolo Testata:
ARCHIVES OF GENERAL PSYCHIATRY
fascicolo: 8, volume: 57, anno: 2000,
pagine: 769 - 775
SICI:
0003-990X(200008)57:8<769:TVRIS>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
GRAY-MATTER VOLUME; SUPERIOR TEMPORAL GYRUS; SEX-DIFFERENCES; BRAIN MORPHOLOGY; FIRST-EPISODE; AFFECTIVE-DISORDER; MONOZYGOTIC TWINS; THOUGHT-DISORDER; RESONANCE; LOBE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Gur, RC Univ Penn, Neuropsychiat Program, 3400 Spruce St,10th Floor,Gates Bldg, Philadelphia, PA 19104 USA Univ Penn 3400 Spruce St,10th Floor,Gates Bldg Philadelphia PA USA 19104
Citazione:
R.E. Gur et al., "Temporolimbic volume reductions in schizophrenia", ARCH G PSYC, 57(8), 2000, pp. 769-775

Abstract

Background: Neuroanatomic studies of schizophrenia have reported temporolimbic abnormalities. Most magnetic resonance imaging studies have evaluated small samples of primarily men with chronic schizophrenia. Our goal was to evaluate sex differences in segmented temporal lobe subregions with reliable parcellation methods, relating volume with clinical and neurocognitive parameters. Methods: Magnetic resonance imaging was performed in 100 patients with schizophrenia (58 men, 42 women; 39 neuroleptic naive, 61 previously treated) and 110 healthy controls (51 men, 59 women). Gray and white matter volumes of temporolimbic (hippocampus and amygdala) and neocortical regions (superior temporal gyrus and temporal pole) were examined. Symptoms, functioning, and neurocognition were assessed concurrently. Results: Hippocampal gray matter volume was reduced in men (7%) and women (8.5%) with schizophrenia. In the amygdala, however, decreased volume was evident for men (8%) whereas women (10.5%) had increased volume. Magnetic resonance imaging of the temporal pole showed decreased gray matter in men (10%) and women (8.5%). For the superior temporal gyrus, the decrease exceeded that of whole-brain only in men (11.5%). Volumes were largely uncorrelated with clinical measures, but higher hippocampal volumes were associated with better memory performance for all groups. Cortical volumes were associated with better memory performance in healthy women. Conclusion: Schizophrenia is associated with reduced gray matter volume intemporolimbic structures. In men, reduction was manifested in all regions,whereas women showed decreased hippocampal volumes but increased amygdala volumes. The abnormalities are evident in patients with first-episode schizophrenia and correlate more strongly with cognitive performance than with symptom severity.

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Documento generato il 22/01/20 alle ore 12:30:58