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Titolo:
24-hour monitoring of cortisol and corticotropin secretion in psychotic and nonpsychotic major depression
Autore:
Posener, JA; DeBattista, C; Williams, GH; Kraemer, HC; Kalehzan, BM; Schatzberg, AF;
Indirizzi:
Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA WashingtonUniv St Louis MO USA 63110 pt Psychiat, St Louis, MO 63110 USA Methropolitan St Louis Psychiat Ctr, St Louis, MO USA Methropolitan St Louis Psychiat Ctr St Louis MO USA tr, St Louis, MO USA Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 t & Behav Sci, Stanford, CA 94305 USA Brigham & Womens Hosp, Div Psychiat, Boston, MA 02115 USA Brigham & WomensHosp Boston MA USA 02115 Psychiat, Boston, MA 02115 USA Brigham & Womens Hosp, Div Endocrine Hypertens, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 Hypertens, Boston, MA 02115 USA McLean Hosp, Belmont, MA 02178 USA McLean Hosp Belmont MA USA 02178McLean Hosp, Belmont, MA 02178 USA Harvard Univ, Sch Med, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 vard Univ, Sch Med, Boston, MA 02115 USA
Titolo Testata:
ARCHIVES OF GENERAL PSYCHIATRY
fascicolo: 8, volume: 57, anno: 2000,
pagine: 755 - 760
SICI:
0003-990X(200008)57:8<755:2MOCAC>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEXAMETHASONE SUPPRESSION TEST; ENDOGENOUS-DEPRESSION; AFFECTIVE-DISORDER; ADRENOCORTICOTROPIN; OUTPATIENTS; SUBTYPES; HORMONE; ILLNESS; RHYTHMS; STRESS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Posener, JA Washington Univ, Sch Med, Dept Psychiat, 660 S Euclid Ave,Box 8134, St Louis, MO 63110 USA Washington Univ 660 S Euclid Ave,Box 8134 St Louis MO USA 63110
Citazione:
J.A. Posener et al., "24-hour monitoring of cortisol and corticotropin secretion in psychotic and nonpsychotic major depression", ARCH G PSYC, 57(8), 2000, pp. 755-760

Abstract

Background: Considerable research has been devoted to the hypothalamic-pituitary-adrenal (HPA) axis in depression, but relatively little attention has been given to intensive monitoring of hormone secretion over time. Such research is potentially important because the HPA axis has prominent circadian and ultradian periodicity. Comparison of depressed patients with and without psychotic features is also important because HPA axis abnormalities Inay be especially pronounced in psychotic depressed patients. Methods: Eleven patients with psychotic major depression (PMD patients), 38 patients with nonpsychotic major depression (NPMD patients), and 33 healthy control subjects, all drug free, were studied. Patients with PMD and NPMD were outpatients recruited primarily by advertisement. Subjects were admitted to a General Clinical Research Center and had blood drawn through an intravenous line for determination of cortisol and corticotropin (ACTH) levels every hour for 24 hours. Results: Among NPMD patients, the 24-hour cortisol amplitude was significantly (P = .02) reduced in comparison with control subjects, while ACTH indices did not differ between NPMD patients and the control group. Among PMD patients, the ACTH 24-hour mean was significantly (P = .03) increased compared with controls, while PMD patients and the control group did not differ significantly in cortisol indices. Conclusion: In the population studied, PMD and NPMD patients have distinctprofiles of HPA axis dysregulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 14:36:29