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Titolo:
A functional neuroanatomy of ties in Tourette syndrome
Autore:
Stern, E; Silbersweig, DA; Chee, KY; Holmes, A; Robertson, MM; Trimble, M; Frith, CD; Frackowiak, RSJ; Dolan, RJ;
Indirizzi:
Cornell Univ, Weill Med Coll, Dept Psychiat, Funct Neuroimaging Lab, New York, NY 10021 USA Cornell Univ New York NY USA 10021 uroimaging Lab, New York, NY 10021 USA Inst Neurol, Wellcome Dept Cognit Neurol, London WC1N 3BG, England Inst Neurol London England WC1N 3BG nit Neurol, London WC1N 3BG, England Natl Hosp Neurol Dis, London, England Natl Hosp Neurol Dis London England tl Hosp Neurol Dis, London, England Prince Henry Hosp, Inst Neuropsychiat, Sydney, NSW, Australia Prince HenryHosp Sydney NSW Australia opsychiat, Sydney, NSW, Australia
Titolo Testata:
ARCHIVES OF GENERAL PSYCHIATRY
fascicolo: 8, volume: 57, anno: 2000,
pagine: 741 - 748
SICI:
0003-990X(200008)57:8<741:AFNOTI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; CEREBRAL BLOOD-FLOW; OBSESSIVE-COMPULSIVE DISORDER; SUPPLEMENTARY MOTOR AREA; BASAL GANGLIA; CORTICAL AREAS; PREFRONTAL CORTEX; MONOZYGOTIC TWINS; CINGULATE CORTEX; SINGLE SUBJECTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Stern, E Cornell Univ, Weill Med Coll, Dept Psychiat, Funct Neuroimaging Lab, Box 140,Room 1304,525 E 68th St, New York, NY 10021 USA Cornell Univ Box 140,Room 1304,525 E 68th St New York NY USA 10021
Citazione:
E. Stern et al., "A functional neuroanatomy of ties in Tourette syndrome", ARCH G PSYC, 57(8), 2000, pp. 741-748

Abstract

Background: Ties are involuntary, brief, stereotyped motor and vocal behaviors often associated with irresistible urges. They are a defining symptom of the classic neuropsychiatric disorder, Tourette syndrome (TS), and constitute an example of disordered human volition. The neural correlates of ties are not well understood and have not been imaged selectively. Methods: Event-related [O-15]H2O positron emission tomography techniques combined with time-synchronized audio and videotaping were used to determinethe duration of, frequency of, and radiotracer input during ties in each of 72 scans from 6 patients with TS. This permitted a voxel-by-voxel correlational analysis within Statistical Parametric Mapping of patterns of neuralactivity associated with the ties. Results: Brain regions in which activity was significantly correlated withtic occurrence in the group included medial and lateral premotor cortices,anterior cingulate cortex, dorsolateral-rostral prefrontal cortex, inferior parietal cortex, putamen, and caudate, as well as primary motor cortex, the Broca's area, superior temporal gyrus, insula, and claustrum. In an individual patient with prominent coprolalia? such vocal ties were associated with activity in prerolandic and postrolandic language regions, insula, caudate, thalamus, and cerebellum, while activity in sensorimotor cortex was noted with motor ties. Conclusions: Aberrant activity in the interrelated sensorimotor, language,executive, and paralimbic circuits identified in this study may account for the initiation and execution of diverse motor and vocal behaviors that characterize ties in TS, as well as for the urges that often accompany them.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 22:48:00