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Titolo:
A serotonin transporter gene promoter polymorphism (5-HTTLPR) and prefrontal cortical finding in major depression and suicide
Autore:
Mann, JJ; Huang, JY; Underwood, MD; Kassir, SA; Oppenheim, S; Kelly, TM; Dwork, AJ; Arango, V;
Indirizzi:
New York State Psychiat Inst & Hosp, Dept Neurosci, Mental Hlth Clin Res Ctr Study Sucidal Behav, New York, NY 10032 USA New York State Psychiat Inst& Hosp New York NY USA 10032 k, NY 10032 USA Columbia Univ Coll Phys & Surg, Dept Psychiat, New York, NY USA Columbia Univ Coll Phys & Surg New York NY USA sychiat, New York, NY USA
Titolo Testata:
ARCHIVES OF GENERAL PSYCHIATRY
fascicolo: 8, volume: 57, anno: 2000,
pagine: 729 - 738
SICI:
0003-990X(200008)57:8<729:ASTGPP>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIPOLAR AFFECTIVE-DISORDER; CEREBROSPINAL-FLUID MONOAMINE; TRYPTOPHAN-HYDROXYLASE GENE; TRITIATED IMIPRAMINE BINDING; BIOGENIC AMINE METABOLITES; H-3 PAROXETINE BINDING; MESSENGER-RNA; ASSOCIATION ANALYSIS; RECEPTOR-BINDING; FRONTAL-CORTEX;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
125
Recensione:
Indirizzi per estratti:
Indirizzo: Mann, JJ New York State Psychiat Inst & Hosp, Dept Neurosci, Mental Hlth Clin Res Ctr Study Sucidal Behav, 1051 Riverside Dr,Box 42, New York, NY 10032 USA New York State Psychiat Inst & Hosp 1051 Riverside Dr,Box 42 New York NY USA 10032
Citazione:
J.J. Mann et al., "A serotonin transporter gene promoter polymorphism (5-HTTLPR) and prefrontal cortical finding in major depression and suicide", ARCH G PSYC, 57(8), 2000, pp. 729-738

Abstract

Background: Major depression and suicide are associated with fewer serotonin transporter (5-HTT) sites. The 5'-flanking promoter region of the 5-HTT gene has a biallelic insertion/deletion (5-HTTLPR). We assayed prefrontal cortical (PFC) 5-HTT binding in major depression and suicide and examine therelationship to the 5-HTTLPR allele. Methods: Postmortem brain samples from 220 individuals were genotyped for the 5-HTTLPR polymorphism. Binding of 5-HTT was assayed by quantitative autoradiography in the PFC of a subset of subjects (n = 159). Clinical information, including DSM-III-R Axis I diagnoses, was obtained by psychological autopsy and medical chart review. Results: Binding to 5-HTT was lower in the ventral PFC of suicides compared with nonsuicides and was lower throughout the PFC of subjects with a history of major depression. The 5-HTTLPR genotype was associated with major depression but not with suicide or 5-HTT binding. Conclusions: A diffuse reduction of 5-HTT binding in the PFC of individuals with major depression may reflect a widespread impairment of serotonergicfunction consistent with the range of psychopathologic features in major depression. The localized reduction in 5-HTT binding in the ventral PFC of suicides may reflect reduced serotonin input to that brain region, underlying the predisposition to act on suicidal thoughts. The 5-HTTLPR genotype wasnot related to the level of 5-HTT binding and does not explain why 5-HTT binding is lower in major depression or suicide.

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Documento generato il 19/01/20 alle ore 11:50:17