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Titolo:
Lung development and function in preterm infants in the surfactant treatment era.
Autore:
Jobe, AH; Ikegami, M;
Indirizzi:
Childrens Hosp, Med Ctr, Cincinnati, OH 45229 USA Childrens Hosp Cincinnati OH USA 45229 Med Ctr, Cincinnati, OH 45229 USA
Titolo Testata:
ANNUAL REVIEW OF PHYSIOLOGY
, volume: 62, anno: 2000,
pagine: 825 - 846
SICI:
0066-4278(2000)62:<825:LDAFIP>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS SYNDROME; NECROSIS-FACTOR-ALPHA; HUMAN-FETAL LUNG; BRONCHOPULMONARY DYSPLASIA; AMNIOTIC-FLUID; GESTATIONAL-AGE; EXOGENOUS SURFACTANT; PROTEIN-A; GLUCOCORTICOID RECEPTOR; INFLAMMATORY RESPONSE;
Keywords:
lung maturation; respiratory distress syndrome; bronchopulmonary dysplasia; chronic lung disease; alveolarization;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
98
Recensione:
Indirizzi per estratti:
Indirizzo: Jobe, AH Childrens Hosp, Med Ctr, Cincinnati, OH 45229 USA Childrens HospCincinnati OH USA 45229 Cincinnati, OH 45229 USA
Citazione:
A.H. Jobe e M. Ikegami, "Lung development and function in preterm infants in the surfactant treatment era.", ANN R PHYSL, 62, 2000, pp. 825-846

Abstract

Mortality of infants of <1-kg birth weight has decreased because of surfactant treatments, antenatal glucocorticoid treatments, and new ventilation strategies. However, many of these infants develop a chronic lung disease characterized by an arrest of lung development and interference with alveolarization. Antenatal glucocorticoids can induce early lung maturation clinically, but new information from transgenic and other experimental models indicates that traditional explanations for glucocorticoid effects on the developing lung are inadequate. These very preterm infants have lungs with smalllung gas volumes and delicate lung tissue that are susceptible to injury with the initiation of ventilation and subsequent ventilation. Antenatal proinflammatory exposures are frequent in very preterm infants, and postnatal injury is associated with elevations of proinflammatory cytokines in the lungs. One hypothesis is that proinflammatory cytokines can promote or interfere with lung development as well as promote lung injury. Mechanisms of lung injury being characterized in the adult lung may have unique characteristics in the developing lung.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 12:24:44