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Titolo:
Understanding angiogenesis and its clinical applications
Autore:
Suh, DY;
Indirizzi:
Med Coll Georgia, Dept Pediat, Childrens Med Ctr, Augusta, GA 30912 USA Med Coll Georgia Augusta GA USA 30912 rens Med Ctr, Augusta, GA 30912 USA
Titolo Testata:
ANNALS OF CLINICAL AND LABORATORY SCIENCE
fascicolo: 3, volume: 30, anno: 2000,
pagine: 227 - 238
SICI:
0091-7370(200007)30:3<227:UAAICA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; CYTOTOXIC CANCER THERAPIES; SICKLE-CELL DISEASE; ALPHA-V INTEGRINS; TUMOR-GROWTH; IN-VIVO; TYROSINE KINASE; ANTIANGIOGENIC ACTIVITY; ISCHEMIC MYOCARDIUM; MICROVESSEL DENSITY;
Keywords:
angiogenesis; blood coagulation; platelets; integrins; neoplasms; gene therapy;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
131
Recensione:
Indirizzi per estratti:
Indirizzo: Suh, DY Med Coll Georgia, Dept Pediat, Childrens Med Ctr, Room HF-1101,1446 HarperSt, Augusta, GA 30912 USA Med Coll Georgia Room HF-1101,1446 HarperSt Augusta GA USA 30912
Citazione:
D.Y. Suh, "Understanding angiogenesis and its clinical applications", ANN CLIN L, 30(3), 2000, pp. 227-238

Abstract

Angiogenesis is the growth of new vessels from pre-existing blood vessels. Angiogenesis is critical during embryogenesis but occurs minimally in healthy adults, except in wound repair, inflammation, female reproductive organs, and pathologic conditions. Various growth factors and proteins, elementsof the extracellular matrix, components of the coagulation/fibrinolytic system, and platelets interact with the endothelial cells and pericytes of blood vessels to regulate angiogenesis. Characterization of angiogenic factors has revealed that remodeling of the extracellular matrix occurs during angiogenesis, mediated by integrins that are found on the endothelial cell surface membrane. Counter-regulatory antiangiogenic proteins and molecules that show an intricate balance in the regulation of angiogenesis have also been characterized. Components of the coagulation/ fibrinolysis cascade also play a critical role in angiogenesis. Elucidation of the mechanisms of angiogenesis has led to better understanding of certain disease states. Ongoingstudies are evaluating the stimulation of angiogenesis to treat ischemic disorders, and the inhibition of angiogenesis to prevent abnormal proliferation in malignant and non-malignant disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 10:14:09