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Titolo:
alpha-synuclein promotes mitochondrial deficit and oxidative stress
Autore:
Hsu, LJ; Sagara, Y; Arroyo, A; Rockenstein, E; Sisk, A; Mallory, M; Wong, J; Takenouchi, T; Hashimoto, M; Masliah, E;
Indirizzi:
Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA Univ Calif SanDiego La Jolla CA USA 92093 urosci, La Jolla, CA 92093 USA Univ Calif San Diego, Dept Pathol, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 Pathol, La Jolla, CA 92093 USA Univ Calif San Diego, Dept Reprod Med, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 od Med, La Jolla, CA 92093 USA
Titolo Testata:
AMERICAN JOURNAL OF PATHOLOGY
fascicolo: 2, volume: 157, anno: 2000,
pagine: 401 - 410
SICI:
0002-9440(200008)157:2<401:APMDAO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELECTRON-TRANSPORT CHAIN; LEWY BODY DISEASE; PARKINSONS-DISEASE; COMPLEX-I; NACP/ALPHA-SYNUCLEIN; ALZHEIMERS-DISEASE; RESPIRATORY-CHAIN; SKELETAL-MUSCLE; CYTOCHROME-C; PERSYN GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Masliah, E Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 Jolla, CA 92093 USA
Citazione:
L.J. Hsu et al., "alpha-synuclein promotes mitochondrial deficit and oxidative stress", AM J PATH, 157(2), 2000, pp. 401-410

Abstract

Abnormal accumulation of the presynaptic protein alpha-synuclein has recently been implicated in the pathogenesis of Alzheimer's and Parkinson's diseases. Because neurodegeneration in these conditions might be associated with mitochondrial dysfunction and oxidative stress, the effects of alpha-synuclein were investigated in a hypothalamic neuronal cell. line (GT1-7). alpha-Synuclein overexpression in these cells resulted in formation of alpha-synuclein-immunopositive inclusion-like structures and mitochondrial alterations accompanied by increased levels of free radicals and decreased secretion of gonadotropin-releasing hormone. These alterations were ameliorated by pretreatment with anti-oxidants such as vitamin E. Taken together these results suggest that abnormal accumulation of alpha-synuclein could lead to mitochondrial alterations that may result In oxidative stress and, eventually, cell death.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 12:29:36