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Titolo:
Individual immunity and susceptibility to female genital tract infection
Autore:
Witkin, SS; Linhares, I; Giraldo, P; Jeremias, J; Ledger, WJ;
Indirizzi:
Cornell Univ, Weill Med Coll, Dept Obstet & Gynecol, Div Infect Dis & Immunol, New York, NY 10021 USA Cornell Univ New York NY USA 10021 Dis & Immunol, New York, NY 10021 USA Univ Sao Paulo, Sch Med, Hosp Clin, Sao Paulo, Brazil Univ Sao Paulo Sao Paulo Brazil , Sch Med, Hosp Clin, Sao Paulo, Brazil Univ Campinas, Dept Obstet & Gynaecol, Sao Paulo, Brazil Univ Campinas Sao Paulo Brazil ept Obstet & Gynaecol, Sao Paulo, Brazil
Titolo Testata:
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
fascicolo: 1, volume: 183, anno: 2000,
pagine: 252 - 256
SICI:
0002-9378(200007)183:1<252:IIASTF>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR ANTAGONIST GENE; TUMOR-NECROSIS-FACTOR; RECURRENT CANDIDAL VAGINITIS; INFLAMMATORY BOWEL-DISEASE; BLOOD MONONUCLEAR-CELLS; HEAT-SHOCK-PROTEIN; VAGINAL CANDIDIASIS; ANTIBODY-PRODUCTION; INTERFERON-GAMMA; MESSENGER-RNA;
Keywords:
Candida albicans; Chlamydia trachomatis; gene polymorphism; heat shock protein; T(H)1 immune response; T(H)2 immune response;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Witkin, SS Cornell Univ, Weill Med Coll, Dept Obstet & Gynecol, Div InfectDis & Immunol, 515 E 71st St, New York, NY 10021 USA Cornell Univ 515 E 71st St New York NY USA 10021 , NY 10021 USA
Citazione:
S.S. Witkin et al., "Individual immunity and susceptibility to female genital tract infection", AM J OBST G, 183(1), 2000, pp. 252-256

Abstract

The responses to genital tract infection vary among different women to a far greater extent than has previously been appreciated. All women are not genetically identical and have not been exposed to identical environments; therefore it is naive to expect that a particular microorganism will elicit the identical response and have the identical sequelae for each infected individual. The genes inherited from one's parents, which contain specific polymorphisms in immune response genes, greatly influence the direction and magnitude of the immune response to microorganisms. Similarly, extrinsic variables, such as the type or quantity of a specific infection, whether thereis a coinfection with another microorganism, such as an intracellular parasite, and whether an immediate hypersensitivity response is concurrently induced also determine the nature of the host response and thus the consequences of microbial exposure. Finally, factors such as the frequency of sexualintercourse and previous immune sensitization to spermatozoa or other components of a particular ejaculate also influence the outcome. An increased awareness of the uniqueness of each host will lead to the development of more precise individualized treatments and improvements in combating infectious diseases of the female genital tract.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:32:24