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Titolo:
Molecular aspects of bladder carcinoma part II. Molecular diagnostics
Autore:
Kausch, I; Bohle, A;
Indirizzi:
Med Univ Lubeck, Urol Klin, D-23538 Lubeck, Germany Med Univ Lubeck Lubeck Germany D-23538 rol Klin, D-23538 Lubeck, Germany
Titolo Testata:
AKTUELLE UROLOGIE
fascicolo: 4, volume: 31, anno: 2000,
pagine: 212 - 228
SICI:
0001-7868(200007)31:4<212:MAOBCP>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
GER
Soggetto:
TRANSITIONAL-CELL-CARCINOMA; EPIDERMAL-GROWTH-FACTOR; FACTOR-RECEPTOR EXPRESSION; VOIDED URINE CYTOLOGY; LEWIS-X ANTIGEN; TISSUE POLYPEPTIDE ANTIGEN; P53 NUCLEAR OVEREXPRESSION; C-ERBB-2 GENE-PRODUCT; BLOOD-GROUP ANTIGENS; BTA TRAK ASSAY;
Keywords:
bladder neoplasms; tumor markers, biological; biology, molecular; urinalysis; indicators; prognosis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
165
Recensione:
Indirizzi per estratti:
Indirizzo: Bohle, A Med Univ Lubeck, Urol Klin, Ratzeburger Allee 160, D-23538 Lubeck, Germany Med Univ Lubeck Ratzeburger Allee 160 Lubeck Germany D-23538 any
Citazione:
I. Kausch e A. Bohle, "Molecular aspects of bladder carcinoma part II. Molecular diagnostics", AKT UROL, 31(4), 2000, pp. 212-228

Abstract

The current system of classifying bladder carcinoma by stage and histological grade is very useful, yet still has limited ability to predict the natural history or treated natural history of a bladder tumor. Cystoscopy and urine cytology are currently considered the "gold standard" in the diagnosisand follow-up of bladder cancer. Classical urine cytology, however, at least in the diagnosis of G1-tumor, is characterized by a relatively low sensitivity. In the last few years, investigation of the basic mechanisms involved in carcinogenesis and tumor progression by molecular biology has provided a host of markers which are of potential diagnostic or prognostic value for bladder carcinoma. We provide a current, comprehensive review of the literature on bladder tumor markers and summerize their diagnostic and prognostic potential. Conclusions: Under the premise that cystoscopy has never been subjected toevaluation, no diagnostic marker currently exists with a sensitivity and specificity comparable to cystoscopy. The combined analysis of several tumormarkers as in the Immunocyt test seems to be the most promising approach. In the future these rather highly sensitive tests could replace cystoscopy or prolong the intervals between cystoscopies in the follow-up of selected patients. The literature suggests that no single marker is currently able to accurately predict the course of bladder tumors. A combination of prognostic markers could predict which superficial tumors need an aggressive form of therapy and which invasive tumors require adjuvant therapy. Altogether, the most promising markers are, at this point, Ki-67 and p53 expression as well as matrixmetalloproteinase complex and angiogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 16:29:13