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Titolo:
Predictive value of serum interleukin-6 and-8 levels in preterm labor or rupture of the membranes
Autore:
von Minckwitz, G; Grischke, EM; Schwab, S; Hettinger, S; Loibl, S; Aulmann, M; Kaufmann, M;
Indirizzi:
Univ Frankfurt, Dept Obstet & Gynecol, D-60590 Frankfurt, Germany Univ Frankfurt Frankfurt Germany D-60590 col, D-60590 Frankfurt, Germany Univ Heidelberg, Dept Obstet & Gynecol, Heidelberg, Germany Univ Heidelberg Heidelberg Germany bstet & Gynecol, Heidelberg, Germany Univ Heidelberg, Dept Surg, D-6900 Heidelberg, Germany Univ Heidelberg Heidelberg Germany D-6900 rg, D-6900 Heidelberg, Germany
Titolo Testata:
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
fascicolo: 8, volume: 79, anno: 2000,
pagine: 667 - 672
SICI:
0001-6349(200008)79:8<667:PVOSIA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATING PEPTIDE-1 INTERLEUKIN-8; AMNIOTIC-FLUID INTERLEUKIN-6; PREMATURE RUPTURE; HISTOLOGIC CHORIOAMNIONITIS; INTRAAMNIOTIC INFECTION; MATERNAL SERUM; PARTURITION; TERM; CYTOKINES; DELIVERY;
Keywords:
interleukin 6; interleukin 8; preterm labour; preterm rupture of the membranes; prognosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: von Minckwitz, G Univ Frankfurt, Dept Obstet & Gynecol, Theodor Stern Kai 7, D-60590 Frankfurt, Germany Univ Frankfurt Theodor Stern Kai 7 FrankfurtGermany D-60590
Citazione:
G. von Minckwitz et al., "Predictive value of serum interleukin-6 and-8 levels in preterm labor or rupture of the membranes", ACT OBST SC, 79(8), 2000, pp. 667-672

Abstract

Background. The aim of this prospective study was to examine if serum concentrations of cytokines are of value in the identification of patients at risk for preterm delivery. Methods. Interleukin-l beta,2,4,6,8 and tumor necrosis factor alpha were determined between 25 and 37 weeks of gestation in the serum of 72 consecutive patients with preterm labor, 38 patients with preterm rupture of the membranes, and 24 healthy pregnant women as a control group. Material was collected within 18 hours after hospitalization and was immediately centrifugedand shock frozen. Results. Significantly increased serum levels were found for interleukin-6and -8 in patients with preterm labor or preterm rupture of the membranes when compared to the control group (p < 0.001 and p < 0.005, respectively). In patients with preterm rupture of the membranes and interleukin-6 levelsabove the median of 4.0 pg/ml the delivery occurred significantly earlier than in patients with lower levels (1 versus 5.5 days; p = 0.005). Patientsof both pathology groups with detectable (>18 pg/ml). Interleukin-8 levelshad a shorter pregnancy duration when compared to other patients (p = 0.05for preterm labor and p = 0.04 for preterm rupture of the membranes). Interleukin-1 beta,2,4, and tumor necrosis factor alpha were not correlated with clinical outcome. Conclusions. Increased serum interleukin-6 and -8 levels are associated with a shorter interval between onset of preterm rupture of the membranes anddelivery and should therefore be further evaluated for their use in clinical practice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 07:25:19