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Titolo:
Ca2+-Zn2+ permeable AMPA or kainate receptors: possible key factors in selective neurodegeneration
Autore:
Weiss, JH; Sensi, SL;
Indirizzi:
Univ Calif Irvine, Dept Neurol, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 , Dept Neurol, Irvine, CA 92697 USA Univ Calif Irvine, Dept Anat & Neurobiol, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 t & Neurobiol, Irvine, CA 92697 USA Univ Calif Irvine, Dept Neurobiol & Behav, Irvine, CA 92697 USA Univ CalifIrvine Irvine CA USA 92697 obiol & Behav, Irvine, CA 92697 USA
Titolo Testata:
TRENDS IN NEUROSCIENCES
fascicolo: 8, volume: 23, anno: 2000,
pagine: 365 - 371
SICI:
0166-2236(200008)23:8<365:CPAOKR>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYOTROPHIC-LATERAL-SCLEROSIS; CULTURED CORTICAL-NEURONS; FOREBRAIN CHOLINERGIC NEURONS; CEREBELLAR GRANULE CELLS; CA2+ PERMEABILITY; BASAL FOREBRAIN; CA2+-PERMEABLE AMPA/KAINATE; GLUR-B; ACID RECEPTORS; HIPPOCAMPAL-NEURONS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
84
Recensione:
Indirizzi per estratti:
Indirizzo: Weiss, JH Univ Calif Irvine, Dept Neurol, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 rol, Irvine, CA 92697 USA
Citazione:
J.H. Weiss e S.L. Sensi, "Ca2+-Zn2+ permeable AMPA or kainate receptors: possible key factors in selective neurodegeneration", TRENDS NEUR, 23(8), 2000, pp. 365-371

Abstract

Neurological diseases, including global ischemia, Alzheimer's disease and amyotrophic lateral sclerosis, are characterized by selective patterns of neurodegeneration. Most studies of potential glutamate-receptor-mediated contributions to disease have focused on the highly Ca2+-permeable and widely distributed NMDA-receptor channel. However, an alternative hypothesis is that the presence of AMPA- or kainate-receptor channels that are directly permeable to Ca2+ ions (Ca-A/K-receptor channels) is of greater significance to the neuronal loss seen in these conditions. Besides a restricted distribution and high Ca2+ permeability, two other factors make Ca-A/K receptors appealing candidate contributors to selective injury: their high permeabilityto Zn2+ ions and the possibility that their numbers increase in disease-associated conditions. Further characterization of the functions of these channels should result in new approaches to treatment of these conditions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 04:20:47