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Titolo:
CYP2D6*10 alleles are not the determinant of the plasma haloperidol concentrations in Asian patients
Autore:
Shimoda, K; Morita, S; Yokono, A; Someya, T; Hirokane, G; Sunahara, N; Takahashi, S;
Indirizzi:
Shiga Univ Med Sci, Dept Psychiat, Otsu, Shiga 5202192, Japan Shiga Univ Med Sci Otsu Shiga Japan 5202192 t, Otsu, Shiga 5202192, Japan Hachiman Seijukai Hosp, Shiga, Japan Hachiman Seijukai Hosp Shiga JapanHachiman Seijukai Hosp, Shiga, Japan Niigata Univ, Sch Med, Dept Psychiat, Niigata, Japan Niigata Univ Niigata Japan Univ, Sch Med, Dept Psychiat, Niigata, Japan Takashima Gen Hosp, Shiga, Japan Takashima Gen Hosp Shiga JapanTakashima Gen Hosp, Shiga, Japan Dainippon Pharmaceut Co Ltd, Lab Prod Div, Osaka, Japan Dainippon Pharmaceut Co Ltd Osaka Japan Ltd, Lab Prod Div, Osaka, Japan
Titolo Testata:
THERAPEUTIC DRUG MONITORING
fascicolo: 4, volume: 22, anno: 2000,
pagine: 392 - 396
SICI:
0163-4356(200008)22:4<392:CAANTD>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEBRISOQUINE HYDROXYLATION PHENOTYPE; REDUCED HALOPERIDOL; SCHIZOPHRENIC-PATIENTS; POOR METABOLIZERS; OXIDATION; INVOLVEMENT; GENE; AMPLIFICATION; FLUVOXAMINE; DISPOSITION;
Keywords:
haloperidol; cytochrome P450(CYP)2D6; genotype;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Shimoda, K Shiga Univ Med Sci, Dept Psychiat, Seta Tsukinowacho, Otsu, Shiga 5202192,Japan Shiga Univ Med Sci Seta Tsukinowacho Otsu Shiga Japan 5202192 n
Citazione:
K. Shimoda et al., "CYP2D6*10 alleles are not the determinant of the plasma haloperidol concentrations in Asian patients", THER DRUG M, 22(4), 2000, pp. 392-396

Abstract

The authors we investigated the relationship between plasma levels of haloperidol (HAL) and the number of CYP2D6*10(*10) alleles in 66 Japanese inpatients with schizophrenia(male = 61, female = 5) on HAL. Plasma HAL level was determined by an enzyme immunoassay method. Daily dose of HAL was 1.5-36 (mean +/- SD = 12.3 +/- 7.6) mg or 0.02-0.49 (0.21 +/- 0.13) mg/kg body weight. Plasma HAL levels ranged from 1.4 to 47.4 (12.4 +/- 9.5) ng/mL. No significant difference in the plasma HAL levels was observed between the subjects with no, one, and two *10 alleles tone-way analysis of variance: 56.1 +/- 20.3, 61.0 +/- 20.3, and 63.3 +/- 20.3 ;ng/ml/mg/kg, respectively, F(2,63) = 0.65, p = 0.52). These results are not supportive of the previous report that plasma HAL levels can be predicted by the number of *10 alleles in Asian patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 14:49:22