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Titolo:
CYTOTOXIC LESIONS OF THE RETROHIPPOCAMPAL REGION ATTENUATE LATENT INHIBITION BUT SPARE THE PARTIAL-REINFORCEMENT EXTINCTION EFFECT
Autore:
YEE BK; FELDON J; RAWLINS JNP;
Indirizzi:
UNIV OXFORD,DEPT EXPT PSYCHOL,S PARKS RD OXFORD OX1 3UD ENGLAND UNIV OXFORD,DEPT EXPT PSYCHOL OXFORD OX1 3UD ENGLAND TEL AVIV UNIV,DEPT PSYCHOL RAMAT AVIV ISRAEL
Titolo Testata:
Experimental Brain Research
fascicolo: 2, volume: 115, anno: 1997,
pagine: 247 - 256
SICI:
0014-4819(1997)115:2<247:CLOTRR>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
LATERAL SEPTAL-LESIONS; LEARNED IRRELEVANCE; NUCLEUS-ACCUMBENS; VENTRAL STRIATUM; FIMBRIA SECTION; DENTATE GYRUS; NEURONAL LOSS; RATS; AMPHETAMINE; CONTEXT;
Keywords:
ENTORHINAL CORTEX; SUBICULUM; RETROHIPPOCAMPUS; LATENT INHIBITION; PARTIAL REINFORCEMENT EXTINCTION EFFECT; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
B.K. Yee et al., "CYTOTOXIC LESIONS OF THE RETROHIPPOCAMPAL REGION ATTENUATE LATENT INHIBITION BUT SPARE THE PARTIAL-REINFORCEMENT EXTINCTION EFFECT", Experimental Brain Research, 115(2), 1997, pp. 247-256

Abstract

Experiment I assessed the effect of cytotoxic retrohippocampal (entorhinal and extra-subicular cortices) lesions on the development of latent inhibition (LI) using an off-the-baseline, between-subjects, conditioned emotional response paradigm. Sham-operated controls and unoperated rats that had been pre-exposed to a light stimulus prior to light-shock pairings showed less conditioned suppression towards the light stimulus than the nonpre-exposed animals, thus demonstrating LI. However, LI was not evident in rats with retrohippocampal lesions. In experiment 2, the same animals were trained to run in an straight runway for food. Half of the animals were trained under a 50% partial reinforcement schedule (i.e. they were rewarded randomly on half of the acquisition trials) and the other half were trained under a continuous reinforcement schedule (i.e. they were rewarded on every acquisition trial). When tested in extinction, animals trained on the partial reinforcementschedule showed greater persistence than animals trained on continuous reinforcement, thus demonstrating the partial reinforcement extinction effect (FREE). Rats with retrohippocampal lesions showed a FREE that was at least as clear as that seen in the sham-operated controls andin the unoperated animals. It is concluded that cytotoxic lesions of the retrohippocampal region selectively led to an abolition of LI, butspared the FREE, The present study thus provided evidence against thehypothesis that LI and the FREE share a common neural substrate.

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Documento generato il 26/01/20 alle ore 22:47:43