Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Inhibition of adipogenesis by Wnt signaling
Autore:
Ross, SE; Hemati, N; Longo, KA; Bennett, CN; Lucas, PC; Erickson, RL; MacDougald, OA;
Indirizzi:
Univ Michigan, Sch Med, Dept Physiol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 ept Physiol, Ann Arbor, MI 48109 USA Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 Dept Pathol, Ann Arbor, MI 48109 USA
Titolo Testata:
SCIENCE
fascicolo: 5481, volume: 289, anno: 2000,
pagine: 950 - 953
SICI:
0036-8075(20000811)289:5481<950:IOABWS>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
BINDING-PROTEIN-ALPHA; BETA-CATENIN; ADIPOCYTE DIFFERENTIATION; GENE-EXPRESSION; TRANSCRIPTIONAL ACTIVATION; 3T3-L1 ADIPOCYTES; PPAR-GAMMA; FAT PADS; FIBROBLASTS; REGULATOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: MacDougald, OA Univ Michigan, Sch Med, Dept Physiol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 n Arbor, MI 48109 USA
Citazione:
S.E. Ross et al., "Inhibition of adipogenesis by Wnt signaling", SCIENCE, 289(5481), 2000, pp. 950-953

Abstract

Wnts are secreted signaling proteins that regulate developmental processes. Here we show that Wnt signaling, Likely mediated by Wnt-10b, is a molecular switch that governs adipogenesis. Wnt signaling maintains preadipocytes in an undifferentiated state through inhibition of the adipogenic transcription factors CCAAT/enhancer binding protein alpha (C/EBP alpha) and peroxisome proliferator-activated receptor gamma (PPAR gamma). When Wnt signaling in preadipocytes is prevented by overexpression of Axin or dominant-negative TCF4, these cells differentiate into adipocytes. Disruption of Wnt signaling also causes transdifferentiation of myoblasts into adipocytes in vitro,highlighting the importance of this pathway not only in adipocyte differentiation but also in mesodermal cell fate determination.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 17:31:25