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Titolo:
CLONING AND CHROMOSOMAL LOCALIZATION OF A GENE (GPR18) ENCODING A NOVEL-7 TRANSMEMBRANE RECEPTOR HIGHLY EXPRESSED IN SPLEEN AND TESTIS
Autore:
GANTZ I; MURAOKA A; YANG YK; SAMUELSON LC; ZIMMERMAN EM; COOK H; YAMADA T;
Indirizzi:
UNIV MICHIGAN,MED CTR,DEPT SURG,1500 W MED CTR DR,6504 MSRB 1 ANN ARBOR MI 48109 UNIV MICHIGAN,DEPT INTERNAL MED ANN ARBOR MI 48109 UNIV MICHIGAN,DEPT PHYSIOL ANN ARBOR MI 48109 OHIO STATE UNIV,DEPT PHYSIOL COLUMBUS OH 43210
Titolo Testata:
Genomics
fascicolo: 3, volume: 42, anno: 1997,
pagine: 462 - 466
SICI:
0888-7543(1997)42:3<462:CACLOA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT; MEMBERS; FAMILY; CELLS; RNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
I. Gantz et al., "CLONING AND CHROMOSOMAL LOCALIZATION OF A GENE (GPR18) ENCODING A NOVEL-7 TRANSMEMBRANE RECEPTOR HIGHLY EXPRESSED IN SPLEEN AND TESTIS", Genomics, 42(3), 1997, pp. 462-466

Abstract

Using the techniques of relaxed stringency polymerase ase chain reaction and genomic library screening, we have isolated homologous canine and human genes that encode a novel putative seven transmembrane G-protein-linked receptor, The gene encodes an open reading frame (ORF) of 993 bp. The sequences of the canine and human ORFs are highly conserved, sharing 89% nucleotide identity and 92% amino acid similarity between the two species, Northern blot analysis demonstrates that mRNA transcripts of the gene are abundantly expressed in testis and spleen witha lesser degree of expression observed in several other tissues associated with endocrine and immunologic/hematologic function, The gene, designated GPR18, was localized to human chromosome 13q32 using fluorescence in situ hybridization. (C) 1997 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 09:25:22