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Titolo:
Calcium metabolism in sarcoidosis and its clinical implications
Autore:
Conron, M; Young, C; Beynon, HLC;
Indirizzi:
Royal Free Hosp, Dept Med, London NW3 2QG, England Royal Free Hosp London England NW3 2QG Dept Med, London NW3 2QG, England
Titolo Testata:
RHEUMATOLOGY
fascicolo: 7, volume: 39, anno: 2000,
pagine: 707 - 713
SICI:
1462-0324(200007)39:7<707:CMISAI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVE PULMONARY SARCOIDOSIS; LUNG LYMPHOCYTES-T; CORTICOSTEROID-INDUCED OSTEOPOROSIS; CULTURED ALVEOLAR MACROPHAGES; GLUCOCORTICOID-INDUCED OSTEOPOROSIS; KETOCONAZOLE-INDUCED REDUCTION; HORMONE-RELATED PROTEIN; VITAMIN-D METABOLITE; BONE-MINERAL CONTENT; SERUM 1,25-DIHYDROXYVITAMIN-D;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
80
Recensione:
Indirizzi per estratti:
Indirizzo: Beynon, HLC Royal Free Hosp, Dept Med, Pond St, London NW3 2QG, England Royal Free Hosp Pond St London England NW3 2QG 3 2QG, England
Citazione:
M. Conron et al., "Calcium metabolism in sarcoidosis and its clinical implications", RHEUMATOLOG, 39(7), 2000, pp. 707-713

Abstract

Objective. To examine the clinical implications of disturbed calcium metabolism in sarcoidosis and how the pathophysiology affects management strategies. Methods. The literature concerning calcium metabolism in sarcoidosis was reviewed. Results. Dysregulated calcium metabolism is a well-recognized complicationof sarcoidosis, resulting in hypercalcaemia (prevalence 5-10%), hypercalcuria (40-62%) and reduced bone density (40-55%). Extrarenal synthesis of calcitriol [1,25(OH)(2)D-3] is central to the pathogenesis of abnormal calciumhomeostasis, but alterations in parathyroid hormone (PTH) activity and theexpression of PTH-related peptide have also been demonstrated. The immunosuppressive properties of calcitriol suggest that the raised levels seen in sarcoidosis could represent an adaptive response to the undefined antigen that causes sarcoidosis. Conclusions. The mechanisms of abnormal calcium metabolism in sarcoidosis need to be understood when treating hypercalcaemia, hypercalcuria and corticosteroid-induced osteoporosis. Studies are required to determine if the currently available therapies for osteoporosis are safe and effective in sarcoidosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/08/20 alle ore 14:30:56