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Titolo:
In vivo antisense imaging
Autore:
Tavitian, B;
Indirizzi:
CEA, DSV, Serv Hosp Frederic Joliot, INSERM,U334, F-914065 Orsay, France CEA Orsay France F-914065 ic Joliot, INSERM,U334, F-914065 Orsay, France
Titolo Testata:
QUARTERLY JOURNAL OF NUCLEAR MEDICINE
fascicolo: 3, volume: 44, anno: 2000,
pagine: 236 - 255
SICI:
1125-0135(200009)44:3<236:IVAI>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; PEPTIDE NUCLEIC-ACIDS; H-3 LABELED OLIGONUCLEOTIDES; MESSENGER-RNA EXPRESSION; FIBROBLAST GROWTH-FACTOR; SOLID-PHASE EXTRACTION; BLOOD-BRAIN-BARRIER; C-MYC ONCOGENE; IN-VIVO; LIVING CELLS;
Keywords:
oligonucleotides antisense; DNA; RNA; radionuclide imaging;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
157
Recensione:
Indirizzi per estratti:
Indirizzo: Tavitian, B CEA, DSV, Serv Hosp Frederic Joliot, INSERM,U334, F-914065 Orsay, France CEA Orsay France F-914065 NSERM,U334, F-914065 Orsay, France
Citazione:
B. Tavitian, "In vivo antisense imaging", Q J NUCL M, 44(3), 2000, pp. 236-255

Abstract

Antisense oligonucleotides, in short antisense, are small chains of nucleic acids capable to bind to cellular ribonucleic acid (RNA) by a hybridization mechanism. In vitro, antisense are widely used as reagents to detect or block specific RNA sequences. The use of antisense as in vivo diagnostic agents is attractive because it would bring molecular imaging at the level ofgene expression However, oligonucleotides are non-canonical radio-pharmaceuticals and much progress is needed to adapt them to in vivo imaging. The requirements to reach this goal include improvements in radiosynthesis, stability, targeting, and specific and non-specific binding. They will be examined in this review together with the current achievements In the applications of antisense as nuclear medicine radiopharmaceuticals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 07:35:18