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Titolo:
Effects of yohimbine on cerebral blood flow, symptoms, and physiological functions in humans
Autore:
Cameron, OG; Zubieta, JK; Grunhaus, L; Minoshima, S;
Indirizzi:
Univ Michigan, Med Ctr, Dept Psychiat, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 pt Psychiat, Ann Arbor, MI 48109 USA Univ Michigan, Med Ctr, Dept Internal Med, Nucl Med Sect, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 cl Med Sect, Ann Arbor, MI 48109 USA Univ Michigan, Med Ctr, PET Ctr, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 tr, PET Ctr, Ann Arbor, MI 48109 USA Sackler Sch Med, Dept Psychiat, Tel Aviv, Israel Sackler Sch Med Tel Aviv Israel ch Med, Dept Psychiat, Tel Aviv, Israel
Titolo Testata:
PSYCHOSOMATIC MEDICINE
fascicolo: 4, volume: 62, anno: 2000,
pagine: 549 - 559
SICI:
0033-3174(200007/08)62:4<549:EOYOCB>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; POSTTRAUMATIC-STRESS-DISORDER; INSULAR CORTEX STIMULATION; PANIC DISORDER; HUMAN-BRAIN; INTRAVENOUS YOHIMBINE; RECEPTOR SUBTYPES; ANXIETY; PET; LOCALIZATION;
Keywords:
yohimbine; cerebral blood flow; positron emission tomography; interoception; anxiety; human;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
115
Recensione:
Indirizzi per estratti:
Indirizzo: Cameron, OG Univ Michigan, Med Ctr, Dept Psychiat, UH-D9814,1500 Med Ctr Dr, Ann Arbor, MI 48109 USA Univ Michigan UH-D9814,1500 Med Ctr Dr Ann ArborMI USA 48109
Citazione:
O.G. Cameron et al., "Effects of yohimbine on cerebral blood flow, symptoms, and physiological functions in humans", PSYCHOS MED, 62(4), 2000, pp. 549-559

Abstract

Objective: Increases in adrenergic activity are associated with stress, anxiety, and other psychiatric, neurological, and medical disorders. To improve understanding of normal CNS adrenergic function, CBF responses to adrenergic stimulation were determined. Methods: Using PET, the CBF changes afterintravenous yohimbine, an alpha(2)-adrenoreceptor antagonist that producesadrenergic activation, were compared with placebo in nine healthy humans. Heart rate, blood pressure, Pace, plasma catecholamines, and symptom responses were also determined. Results: Among nonscan variables, yohimbine produced significant symptom increases (including a panic attack in one subject), a decrease in Pace, due to hyperventilation, increases in systolic and diastolic blood pressure, and a trend toward a significant norepinephrine increase. Among scan results, yohimbine produced a significant decrease in whole-brain absolute CBF; regional decreases were greatest in cortical areas. Medial frontal cortex, thalamus, insular cortex, and cerebellum showed significant increases after normalization to whole brain. Medial frontal CBF change was correlated with increases in anxiety. A panic attack produced an increase instead of a decrease in whole-brain CBF. Factors potentially contributing to the observed CBF changes were critically reviewed. Specific regional increases were most likely due in large part to activation produced byadrenergically induced anxiety and visceral symptoms. Conclusions: This study supports the relationship of anxiety and interoceptive processes with medial frontal, insular, and thalamic activation and provides a baseline forcomparison of normal yohimbine-induced CNS adrenergic activation, adrenergically-based symptoms, and other markers of adrenergic function to stress, emotion, and the adrenergic pathophysiologies of various CNS-related disorders.

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Documento generato il 23/01/20 alle ore 18:19:47