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Titolo:
Natural animal models of human psychiatric conditions: Assessment of mechanism and validity
Autore:
Overall, KL;
Indirizzi:
Univ Penn, Sch Vet Med, Dept Clin Studies, VHUP, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 ies, VHUP, Philadelphia, PA 19104 USA
Titolo Testata:
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
fascicolo: 5, volume: 24, anno: 2000,
pagine: 727 - 776
SICI:
0278-5846(200007)24:5<727:NAMOHP>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSESSIVE-COMPULSIVE DISORDER; GENERALIZED ANXIETY DISORDER; CORTICOTROPIN-RELEASING HORMONE; BETA-AMYLOID ACCUMULATION; PANIC DISORDER; ALZHEIMERS-DISEASE; AGED DOGS; NORADRENERGIC FUNCTION; COGNITIVE DYSFUNCTION; CLINICAL IMPROVEMENT;
Keywords:
animal model; canine model; cognitive dysfunction dog model; dominance aggression; generalized anxiety disorder; impulse control disorder; obsessive-compulsive disorder; panic disorder; post-traumatic stress disorder; schizophrenia; separation anxiety;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
157
Recensione:
Indirizzi per estratti:
Indirizzo: Overall, KL Univ Penn, Sch Vet Med, Dept Clin Studies, VHUP, 3850 Spruce St, Philadelphia, PA 19104 USA Univ Penn 3850 Spruce St Philadelphia PA USA 19104 A 19104 USA
Citazione:
K.L. Overall, "Natural animal models of human psychiatric conditions: Assessment of mechanism and validity", PROG NEUR-P, 24(5), 2000, pp. 727-776

Abstract

1. The classic animal models for human psychiatric conditions involves rodents. As prey species, their normal behaviors of avoidance would be considered pathological in humans and dogs. Hence. such models may not be homologous for similar behaviors found in psychiatric pathology in humans.2. Dogs exhibit pathological behavioral conditions that may be equivalent to certain human psychiatric conditions. These canine conditions appear spontaneously or endogenously in the absence of genetic or neurochemcial manipulation, and as such, may be homologous to the human condition.3. If canine conditions approach homology with human conditions they should have excellent face, predictive, and construct validity.4. The canine conditions of separation anxiety, obsessive-compulsive disorder, cognitive dysfunction dominance aggression, and panic disorder have good to excellent validity at all explored levels for human generalized anxiety disorder, obsessive-compulsive disorder, Alzheimer's disease, impulse control disorders, and panic disorder.5. Natural canine models can aid our understanding of human psychiatric conditions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 18:29:35