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Titolo:
Cluster analysis of diffusion tensor magnetic resonance images in human head injury
Autore:
Jones, DK; Dardis, R; Ervine, M; Horsfield, MA; Jeffree, M; Simmons, A; Jarosz, J; Strong, AJ;
Indirizzi:
Univ London Kings Coll Hosp, Sch Med, London SE5 9RS, England Univ London Kings Coll Hosp London England SE5 9RS ndon SE5 9RS, England St Thomas Hosp, Sch Med, Kings Coll, London SE5 9RS, England St Thomas Hosp London England SE5 9RS ings Coll, London SE5 9RS, England Guys Hosp, Sch Med, Kings Coll, London SE5 9RS, England Guys Hosp LondonEngland SE5 9RS ed, Kings Coll, London SE5 9RS, England Univ London Kings Coll, Inst Psychiat, Old Age Psychiat Sect, London WC2R 2LS, England Univ London Kings Coll London England WC2R 2LS London WC2R 2LS, England Inst Psychiat, Dept Clin Neurosci, London, England Inst Psychiat London England chiat, Dept Clin Neurosci, London, England Univ London Kings Coll Hosp, Dept Anaesthesia, London, England Univ LondonKings Coll Hosp London England Anaesthesia, London, England Univ Leicester, Leicester Royal Infirm, Div Med Phys, Leicester LE1 7RH, Leics, England Univ Leicester Leicester Leics England LE1 7RH er LE1 7RH, Leics, England
Titolo Testata:
NEUROSURGERY
fascicolo: 2, volume: 47, anno: 2000,
pagine: 306 - 313
SICI:
0148-396X(200008)47:2<306:CAODTM>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRAUMATIC BRAIN INJURY; ISCHEMIC RAT-BRAIN; ECHO-PLANAR IMAGES; APPARENT DIFFUSION; CEREBRAL-ISCHEMIA; WATER DIFFUSION; HUMAN STROKE; MRI; NMR; MODEL;
Keywords:
cluster analysis; diffusion tensor; edema; magnetic resonance imaging; MRI; traumatic brain injury;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Strong, AJ Univ London Kings Coll Hosp, Sch Med, London SE5 9RS, England Univ London Kings Coll Hosp London England SE5 9RS S, England
Citazione:
D.K. Jones et al., "Cluster analysis of diffusion tensor magnetic resonance images in human head injury", NEUROSURGER, 47(2), 2000, pp. 306-313

Abstract

OBJECTIVE: issues surrounding the nature of the edema associated with traumatic brain injury in humans, and its evolution in the acute phase, remain unresolved. This study aimed to characterize the topographical nature of the pathophysiological changes in human traumatic brain injury with diffusiontensor magnetic resonance imaging. METHODS: Multislice diffusion-weighted magnetic resonance imaging data were acquired from five patients undergoing elective ventilation for management of traumatic focal contusion or hematomas. The diffusion tensor and the Ta-weighted intensity were then computed for every voxel in the image data set for each patient The topographical distribution of abnormalities in the trace of the diffusion tensor and T2-weighted images were characterized by cluster analysis. RESULTS: In four patients with technically satisfactory data, a narrow band of tissue was observed in the periphery of focal lesions, which was characterized by selective reduction in the trace of the diffusion tensor, without any associated increase in the T2-weighted signal intensity. CONCLUSION: This change is interpreted as indicating either a partial redistribution of water from the extra- to intracellular compartment, or a reduction in the diffusivity of water in the intracellular or cytosolic environment. These diffusion and T2-weighted characteristics are also found in early ischemic change, hence, such regions may represent potentially salvageable tissue at risk of permanent damage. The study illustrates the advantage of using information contained within the diffusion tensor in addition to more conventional imaging sequences.

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Documento generato il 01/04/20 alle ore 23:41:53