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Titolo:
Central neural regulation of penile erection
Autore:
Giuliano, F; Rampin, O;
Indirizzi:
CHU Bicetre, Serv Urol, Assistance Publ Hosp Paris, F-94270 Le Kremlin Bicetre, France CHU Bicetre Le Kremlin Bicetre France F-94270 Le Kremlin Bicetre, France INRA, Lab Neurobiol Fonct Vegetat, F-78352 Jouy En Josas, France INRA Jouy En Josas France F-78352 Vegetat, F-78352 Jouy En Josas, France
Titolo Testata:
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
fascicolo: 5, volume: 24, anno: 2000,
pagine: 517 - 533
SICI:
0149-7634(200007)24:5<517:CNROPE>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT SPINAL-CORD; MEDIAL PREOPTIC AREA; NITRIC-OXIDE SYNTHASE; THYROTROPIN-RELEASING-HORMONE; INTERMEDIOLATERAL CELL COLUMN; SYMPATHETIC PREGANGLIONIC NEURONS; DOPAMINE-RECEPTOR AGONIST; MASCULINE SEXUAL-BEHAVIOR; VASOACTIVE INTESTINAL POLYPEPTIDE; FACILITATES SEMINAL EMISSION;
Keywords:
penile erection; lumbosacral spinal cord; genital reflexes; serotonin; dopamine; noradrenaline; oxytocin; raphe nuclei; medial preoptic area; paraventricular nucleus;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
261
Recensione:
Indirizzi per estratti:
Indirizzo: Giuliano, F CHU Bicetre, Serv Urol, Assistance Publ Hosp Paris, F-94270 LeKremlin Bicetre, France CHU Bicetre Le Kremlin Bicetre France F-94270 icetre, France
Citazione:
F. Giuliano e O. Rampin, "Central neural regulation of penile erection", NEUROSCI B, 24(5), 2000, pp. 517-533

Abstract

Penile erection is caused by a change of the activity of efferent autonomic pathways to the erectile tissues and of somatic pathways to the perineal striated muscles. The spinal cord contains the cell bodies of autonomic andsomatic motoneurons that innervate the peripheral targets. The sympatheticoutflow is mainly antierectile, the sacral parasympathetic outflow is proerectile, and the pudendal outflow, through contraction of the perineal striated muscles, enhances an erection already present. The shift from flaccidity to erection suggests relations among these neuronal populations in response to a variety of informations. Spinal neurons controlling erection are activated by information from peripheral and supraspinal origin. Both peripheral and supraspinal information is capable of eliciting erection, or modulating or inhibiting an erection already present. One can hypothesize a spinal network consisting of primary afferents from the genitals, spinal interneurons and sympathetic, parasympathetic and somatic nuclei. This system is capable of integrating information from the periphery and eliciting reflexive erections. The same spinal network, eventually including different populations of spinal interneurons, would be the recipient of supraspinal information. Premotor neurons that project directly onto spinal sympathetic, parasympathetic or somatic motoneurons, are present in the medulla, pens and diencephalon. Several of these premotor neurons may in rum be activated by sensory information from the genitals. Aminergic and peptidergic descending pathways in the vicinity of spinal neurons, exert complex effects on the spinal network that control penile erection. This is caused by the potential interaction of a great variety of receptors and receptor subtypes present inthe spinal cord, Brainstem and hypothalamic nuclei (among the latter, the paraventricular nucleus and the medial preoptic area) may not necessarily reach spinal neurons directly. However they are prone to regulate penile erection in more integrated and coordinated responses of the body, such as those occurring during sexual behavior. Finally, the central and spinal role of regulatory peptides (oxytocin, melanocortins, endorphins) has only recently been elucidated. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 10:22:25