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Titolo:
5-HT1A and 5-HT1B/1D receptors are involved in the modulation of the trigeminovascular system of the cat: a microiontophoretic study
Autore:
Boers, PM; Donaldson, C; Zagami, AS; Lambert, GA;
Indirizzi:
Prince Henry Hosp, Inst Neurol Sci, Randwick, NSW 2031, Australia Prince Henry Hosp Randwick NSW Australia 2031 ndwick, NSW 2031, Australia Prince Wales Hosp, Inst Neurol Sci, Randwick, NSW 2031, Australia Prince Wales Hosp Randwick NSW Australia 2031 ndwick, NSW 2031, Australia St George Hosp, Dept Med, Sydney, NSW, Australia St George Hosp Sydney NSW Australia sp, Dept Med, Sydney, NSW, Australia Univ New S Wales, Sydney, NSW, Australia Univ New S Wales Sydney NSW Australia ew S Wales, Sydney, NSW, Australia
Titolo Testata:
NEUROPHARMACOLOGY
fascicolo: 10, volume: 39, anno: 2000,
pagine: 1833 - 1847
SICI:
0028-3908(2000)39:10<1833:5A5RAI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
H-3 SUMATRIPTAN-BINDING; GUINEA-PIG BRAIN; DIVERGENT AXON COLLATERALS; CENTRAL-NERVOUS-SYSTEM; MEDULLARY DORSAL HORN; TRIGEMINAL NEURONS; SPINAL-CORD; DIFFERENTIAL DISTRIBUTION; NOCICEPTIVE NEURONS; ZOLMITRIPTAN 311C90;
Keywords:
(+)8-OH-DPAT; WAY-100635; alniditan; GR-127935; migraine; trigeminovascular;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
76
Recensione:
Indirizzi per estratti:
Indirizzo: Boers, PM Prince Henry Hosp, Inst Neurol Sci, Level 2,High St Bldg, Randwick, NSW 2031, Australia Prince Henry Hosp Level 2,High St Bldg Randwick NSWAustralia 2031
Citazione:
P.M. Boers et al., "5-HT1A and 5-HT1B/1D receptors are involved in the modulation of the trigeminovascular system of the cat: a microiontophoretic study", NEUROPHARM, 39(10), 2000, pp. 1833-1847

Abstract

Electrical stimulation of the superior sagittal sinus in the cat activatedneurones in the trigeminal nucleus caudalis. The mean latency of these responses (10.1 ms) was consistent with activation of A delta-fibres. Microiontophoretic ejection of either the selective serotonin(1A) (5-HT1A) agonist (+)8-OH-DPAT or the 5-HT1B/1D agonist alniditan resulted in the reversible suppression of the response to superior sagittal sinus stimulation of 29/46and 18/20 trigeminal neurones, respectively. The response to sagittal sinus stimulation was suppressed by 39+/-5% (n=46) by (+)8-OH-DPAT and 65+/-5% (n=20) by alniditan. Microiontophoretic ejection of the selective 5-HT1A receptor antagonist WAY-100635 significantly antagonised the effect of (+)8-OH-DPAT (effect reduced by 30%, P<0.05). The ejection of GR-127935, a selective 5-HT1B/1D, antagonist, significantly antagonised the effect of alniditan (effect reduced by 52%, P<0.02). In eight neurones the response to convergent facial receptive field stimulation was also tested in the presence of alniditan. Only 4/8 receptive field responses were suppressed by alniditan (compared to 8/8 sagittal sinus responses) and alniditan had significantly less quantitative effect on the response to receptive field stimulation than on the response to sagittal sinus stimulation in the same neurones (mean reduction 36+/-14% and 66+/-8%, respectively, P<0.05). These results suggest that pharmacological modulation of the trigeminovascular system can occurat the first central synapse and that, in addition to 5-HT1B/1D receptors,5-HT1A receptors may be involved in the modulation of sensory neurotransmission in the trigeminovascular system. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 01:58:55