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Titolo:
Age-related decline in brain white matter anisotropy measured with spatially corrected echo-planar diffusion tensor imaging
Autore:
Pfefferbaum, A; Sullivan, EV; Hedehus, M; Lim, KO; Adalsteinsson, E; Moseley, M;
Indirizzi:
SRI Int, Neuropsychiat Program, Menlo Park, CA 94025 USA SRI Int Menlo Park CA USA 94025 sychiat Program, Menlo Park, CA 94025 USA Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 t & Behav Sci, Stanford, CA 94305 USA Stanford Univ, Sch Med, Dept Radiol, Stanford, CA 94305 USA Stanford UnivStanford CA USA 94305 , Dept Radiol, Stanford, CA 94305 USA Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USA Nathan S Kline Inst Psychiat Res Orangeburg NY USA 10962 rg, NY 10962 USA
Titolo Testata:
MAGNETIC RESONANCE IN MEDICINE
fascicolo: 2, volume: 44, anno: 2000,
pagine: 259 - 268
SICI:
0740-3194(200008)44:2<259:ADIBWM>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN CORPUS-CALLOSUM; HUMAN CEREBRAL-CORTEX; GRAY-MATTER; SIGNAL HYPERINTENSITIES; FIBER COMPOSITION; IN-VIVO; MRI; IMAGES; TISSUES; SCHIZOPHRENIA;
Keywords:
diffusion imaging; echo planar imaging; white matter; aging; brain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Pfefferbaum, A SRI Int, Neuropsychiat Program, 333 Ravenswood Ave, Menlo Park, CA 94025 USA SRI Int 333 Ravenswood Ave Menlo Park CA USA 94025 4025 USA
Citazione:
A. Pfefferbaum et al., "Age-related decline in brain white matter anisotropy measured with spatially corrected echo-planar diffusion tensor imaging", MAGN RES M, 44(2), 2000, pp. 259-268

Abstract

Echo planar (EP) diffusion tensor imaging (DTI) permits in vivo identification of the orientation and coherence of brain white matter tracts but suffers from field inhomogeneity-induced geometric distortion. To reduce spatial distortion, polynomial warping corrections were applied and the effects tested on measures of fractional anisotropy (FA) in the genu and splenium ofcorpus callosum. Implementation entailed spatially warping EP images obtained without diffusion weighting (b = 0) to long-echo T-2-weighted fast spinecho images, collected for anatomical delineation, tissue segmentation, and coregistration with the diffusion images. Using the optimal warping procedure (third-order polynomial), the effects of age on FA and a quantitative measure of intervoxel coherence (C) in the genu, splenium, centrum semiovale, and frontal and parietal pericallosal white matter were examined in 31 healthy men (23-76 years). FA declined significantly with age in all regionsexcept the splenium, whereas intervoxel coherence positively correlated with age in the genu. Magn Reson Med 44:259-268, 2000. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 08:53:30