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Titolo:
The proteins of the actin cytoskeleton: well placed for motility
Autore:
Golsteyn, RM; Arpin, M; Friederich, E; Louvard, D;
Indirizzi:
Inst Curie, CNRS, UMR 144, F-75248 Paris 05, France Inst Curie Paris France 05 urie, CNRS, UMR 144, F-75248 Paris 05, France
Titolo Testata:
M S-MEDECINE SCIENCES
fascicolo: 6-7, volume: 16, anno: 2000,
pagine: 722 - 731
SICI:
0767-0974(200006/07)16:6-7<722:TPOTAC>2.0.ZU;2-W
Fonte:
ISI
Lingua:
FRE
Soggetto:
ALDRICH-SYNDROME PROTEIN; AMINO-TERMINAL DOMAIN; HUMAN ARP2/3 COMPLEX; LISTERIA-MONOCYTOGENES; FOCAL ADHESION; MICROFILAMENT DYNAMICS; EPITHELIAL-CELLS; MAMMALIAN-CELLS; F-ACTIN; EZRIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Louvard, D Inst Curie, CNRS, UMR 144, 26 Rue Ulm, F-75248 Paris 05, FranceInst Curie 26 Rue Ulm Paris France 05 F-75248 Paris 05, France
Citazione:
R.M. Golsteyn et al., "The proteins of the actin cytoskeleton: well placed for motility", M S-MED SCI, 16(6-7), 2000, pp. 722-731

Abstract

The cells of our body are capable of a tremendous variety of movements that require the coordination of the actin cytoskeleton, a complex network of proteins. At the heart of this network, actin is attributed with the dynamic properties of alternating between a monomer and a long polymer chain. Oneof the major problems in biology has been to understand how the simple process of actin polymerisation and depolymerisation can orchestrate the complex cell movement necessary for embryogenesis, immune response, and wound repair. In this review, we focus on three different, but related systems thatplay a major role in regulating the actin cytoskeleton. Two of these systems, represented by the Arp2/3 complex and zyxin, appear to be important in controlling actin polymerisation by different mechanisms acting at different locations in the cell. A third major system is represented by ezrin, which, in addition to its direct interaction with actin, can regulate the actincytoskeleton and affect cell movement and survival. To unravel the complexities of cell movement and the actin cytoskeleton has been a major challenge, but the use of many different experimental systems has has now given us an integrated view of cell motility.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 21:58:24