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Titolo:
Diffuse intimal thickening of coronary arteries in patients with coronary spastic angina
Autore:
Miyao, Y; Kugiyama, K; Kawano, H; Motoyama, T; Ogawa, H; Yoshimura, M; Sakamoto, T; Yasue, H;
Indirizzi:
Kumamoto Univ, Sch Med, Dept Cardiovasc Med, Kumamoto 8608556, Japan Kumamoto Univ Kumamoto Japan 8608556 iovasc Med, Kumamoto 8608556, Japan
Titolo Testata:
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
fascicolo: 2, volume: 36, anno: 2000,
pagine: 432 - 437
SICI:
0735-1097(200008)36:2<432:DITOCA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE ACTIVITY; VARIANT ANGINA; INTRAVASCULAR ULTRASOUND; CHRONIC INHIBITION; SYNTHASE GENE; HEART-DISEASE; RISK-FACTORS; ATHEROSCLEROSIS; ACETYLCHOLINE; FLOW;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Yasue, H Kumamoto Univ, Sch Med, Dept Cardiovasc Med, Honjo 1-1-1, Kumamoto 8608556, Japan Kumamoto Univ Honjo 1-1-1 Kumamoto Japan 8608556 8608556, Japan
Citazione:
Y. Miyao et al., "Diffuse intimal thickening of coronary arteries in patients with coronary spastic angina", J AM COL C, 36(2), 2000, pp. 432-437

Abstract

OBJECTIVES The purpose of this study was to evaluate the extent of atherosclerotic changes in angiographically normal coronary arteries using intravascular ultrasound (IVUS) technique in patients with coronary spastic angina. BACKGROUND Nitric oxide activity was shown to be decreased in coronary arteries of patients with coronary spastic angina (CSA). Decrease in nitric oxide causes arterial intimal hyperplasia or thickening. However, it remains unclear whether intimal thickening is diffusely present in coronary arteries of patients with CSA. METHODS The IVUS study was performed in 26 patients with CSA and with. normal coronary angiograms and in 31 control subjects in whom age and gender was matched with those in patients with CSA. RESULTS Compared with control subjects, patients with CSA had significantly larger percent intima + media area (%I + M area), intima + media area andmaximal intima di media thickness in all of proximal, middle and distal segments (p < 0.01, respectively). Lumen area was comparable between these groups. The presence of spasm was the most powerful independent predictor of increase in percent intima + media area, in multiple-regression analysis with the traditional risk factors as covariates. CONCLUSIONS Intimal thickening existed entirely in a coronary artery in patients with CSA and with normal angiograms, independently of other traditional risk factors. The diffuse intimal thickening in the spasm coronary arteries is intimately related with coronary spasm. (C) 2000 by the American College of Cardiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 13:20:45