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Titolo:
Tissue oxygen pressure during prolonged ischemia of the liver
Autore:
Hiratsuka, K; Kim, YI; Nakashima, K; Kawano, K; Yoshida, T; Kitano, S;
Indirizzi:
Oita Med Univ, Dept Surg 1, Hasama, Oita 8795593, Japan Oita Med Univ Hasama Oita Japan 8795593 rg 1, Hasama, Oita 8795593, Japan Kyungpook Natl Univ Hosp, Liver Transplantat Ctr, Taegu 700721, South Korea Kyungpook Natl Univ Hosp Taegu South Korea 700721 gu 700721, South Korea
Titolo Testata:
JOURNAL OF SURGICAL RESEARCH
fascicolo: 2, volume: 92, anno: 2000,
pagine: 250 - 254
SICI:
0022-4804(200008)92:2<250:TOPDPI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR INFLOW OCCLUSION; PRINGLE MANEUVER; BLOOD-FLOW; RESECTION; EXCLUSION; TOLERANCE; PIG; MANAGEMENT; TUMORS;
Keywords:
liver ischemia; hepatic tissue oxygen pressure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Hiratsuka, K Oita Med Univ, Dept Surg 1, 1-1 Idaigaoka, Hasama, Oita 8795593, Japan Oita Med Univ 1-1 Idaigaoka Hasama Oita Japan 8795593 , Japan
Citazione:
K. Hiratsuka et al., "Tissue oxygen pressure during prolonged ischemia of the liver", J SURG RES, 92(2), 2000, pp. 250-254

Abstract

Background The potential role of hepatovenous back-perfusion in maintaining organ viability of the inflow-occluded liver has been reported with respect to aspects of tissue perfusion and energy metabolism. In the present study, the physiological differences between liver ischemia induced by portal triad clamping (PTC) and that induced by total hepatic vascular exclusion (THVE) were investigated in a porcine disease model, with special reference to changes in tissue oxygen pressure (PtO2) of the liver. Materials and methods. Twelve female pigs were used for induction of 60 min of normothermic liver ischemia, They were assigned to two groups: a PTC group (n = 6) and a THVE group (n = 6), PtO2 was measured before, during, and after the ischemic period at two different points in the middle lobe: on the central side close to the hepatovenous confluence and on the peripheralside close to the gallbladder bed. Results. Although central PtO2 decreased during ischemia in both groups, PTC group values at 40 and 60 min of ischemia remained significantly higher than THVE group values (60 +/- 28 and 42 +/- 21 mmHg vs 11 +/- 5 and 13 +/-3 mmHg, respectively; means +/- SD). Peripheral PtO2 in the PTC group during ischemia was low in comparison to corresponding central PtO2 values. Conclusion. Oxygen supply to the tissue via hepatovenous reflux may contribute to maintaining organ viability under prolonged inflow occlusion of theliver. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 11:52:42