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Titolo:
Artificial formula induces precocious maturation of the small intestine ofartificially reared suckling rats
Autore:
Dvorak, B; McWilliam, DL; Williams, CS; Dominguez, J; Machen, NW; McCuskey, RS; Philipps, AF;
Indirizzi:
Univ Arizona, Dept Pediat, Tucson, AZ 85724 USA Univ Arizona Tucson AZ USA 85724 izona, Dept Pediat, Tucson, AZ 85724 USA Univ Arizona, Steel Mem Childrens Res Ctr, Tucson, AZ 85724 USA Univ Arizona Tucson AZ USA 85724 Childrens Res Ctr, Tucson, AZ 85724 USA Univ Arizona, Dept Cell Biol & Anat, Tucson, AZ 85724 USA Univ Arizona Tucson AZ USA 85724 t Cell Biol & Anat, Tucson, AZ 85724 USA
Titolo Testata:
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
fascicolo: 2, volume: 31, anno: 2000,
pagine: 162 - 169
SICI:
0277-2116(200008)31:2<162:AFIPMO>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIFFERENT MILK-SUBSTITUTES; GASTROINTESTINAL-TRACT; NUTRITION RESEARCH; SUCRASE ACTIVITY; PUPS; GROWTH; METABOLISM; PROTEIN; CORTICOSTERONE; INFANTS;
Keywords:
artificial rearing; gastrointestinal tract; infant nutrition; rat's milk; small intestine; suckling rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Dvorak, B Univ Arizona, Dept Pediat, 1501 N campbell Ave,POB 245073, Tucson, AZ 85724 USA Univ Arizona 1501 N campbell Ave,POB 245073 Tucson AZ USA 85724
Citazione:
B. Dvorak et al., "Artificial formula induces precocious maturation of the small intestine ofartificially reared suckling rats", J PED GASTR, 31(2), 2000, pp. 162-169

Abstract

Background: The artificially reared rat model was used successfully to study the effect of nutrition during the early postnatal period on growth and development of the neonate. Overgrowth and morphologic changes of the gastrointestinal tract are known consequences of artificial rearing. The major goal of our study was to elucidate whether artificial rearing-enhanced gut development is caused by artificial diet or by gastrostomy and the artificial rearing technique itself. Methods: Suckling rats at day 8 of age underwent intragastric cannulation and were machine fed either a cow's milk-based artificial rat's milk substitute or pooled rat's milk for 4 days. Dam-fed littermates served as a control. Results: Body growth did not differ in the three experimental groups. In rats receiving rat's milk substitute, small intestinal wet weight was approximately 60% greater than in rats fed rat's milk or control rats. Additionally, the entire small intestine was approximately 20% longer in the mt's milk substitute group. Morphologically, mt's milk substitute-fed pups demonstrated significantly greater intestinal villus length and crypt depth compared with rat's milk-fed or control rats. Jejunum and mid-jejunum of the rat'smilk and control groups did not differ in these parameters. Intestinal sucrase activity of rat's milk substitute-fed rats was significantly elevated compared with rat's milk-fed rats or control animals. Conclusions: These results indicate that cow's milk-based formula, not gastrostomy or artificial feeding technique, is a principal cause of the smallintestine overgrowth and precocious maturation of some intestinal functions observed in artificially reared sucklings.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 06:42:20