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Titolo:
Mannosylated lipoarabinomannan antagonizes Mycobacterium tuberculosis-induced macrophage apoptosis by altering Ca+2-dependent cell signaling
Autore:
Rojas, M; Garcia, LF; Nigou, J; Puzo, G; Olivier, M;
Indirizzi:
Univ Antiquia, Fac Med, Ctr Invest Med, Lab Cent Invest,Grp Inmunol Celular & Inmunogenet, Medellin AA1226, Colombia Univ Antiquia Medellin Colombia AA1226 ogenet, Medellin AA1226, Colombia CHU Laval, Lab Infectiol, Quebec City, PQ G1V 4G2, Canada CHU Laval Quebec City PQ Canada G1V 4G2 , Quebec City, PQ G1V 4G2, Canada CNRS, Inst Pharmacol & Biol Struct, Toulouse, France CNRS Toulouse France RS, Inst Pharmacol & Biol Struct, Toulouse, France
Titolo Testata:
JOURNAL OF INFECTIOUS DISEASES
fascicolo: 1, volume: 182, anno: 2000,
pagine: 240 - 251
SICI:
0022-1899(200007)182:1<240:MLAMT>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; NITRIC-OXIDE; MURINE MACROPHAGES; CREB PHOSPHORYLATION; GENE-EXPRESSION; FACTOR-ALPHA; CYCLIC-AMP; NUCLEAR SCAFFOLD; NO SYNTHASE; TNF-ALPHA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
72
Recensione:
Indirizzi per estratti:
Indirizzo: Garcia, LF Univ Antiquia, Fac Med, Ctr Invest Med, Lab Cent Invest,Grp Inmunol Celular & Inmunogenet, Medellin AA1226, Colombia Univ Antiquia Medellin Colombia AA1226 ellin AA1226, Colombia
Citazione:
M. Rojas et al., "Mannosylated lipoarabinomannan antagonizes Mycobacterium tuberculosis-induced macrophage apoptosis by altering Ca+2-dependent cell signaling", J INFEC DIS, 182(1), 2000, pp. 240-251

Abstract

Mycobacterium tuberculosis-induced macrophage apoptosis can be inhibited by mannosylated lipoarabinomannan (ManLAM), although it induces tumor necrosis factor (TNF)-alpha and NO production, which participate in apoptosis induction. ManLAM also modulates Ca+2- dependent intracellular events, and Ca+2 participates in apoptosis in different systems. Ca+2 was assessed for involvement in M, tuberculosis-induced macrophage apoptosis and for modulationby ManLAM, The role of Ca+2 was supported by the blockade of apoptosis by cAMP inhibitors and the Ca+2 chelator, BAPTA/AM, These agents also inhibited caspase-1 activation and cAMP-responsive element-binding protein translocation without affecting TNF-alpha production. Infection of macrophages withM, tuberculosis induced an influx of Ca+2 that was prevented by ManLAM, Similarly, M. tuberculosis infection-altered mitochondrial permeability transition was prevented by ManLAM and BAPTA/AM. Finally, ManLAM and BAPTA/AM reversed the effects of nl. tuberculosis on p53 and Bcl-2 expression. ManLAM counteracts the alterations of calcium-dependent intracellular events that occur during M. tuberculosis-induced macrophage apoptosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 16:07:58