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Titolo:
Assessing cardiovascular autonomic neuropathy in diabetes mellitus - How many tests to use?
Autore:
May, O; Arildsen, H;
Indirizzi:
Odense Univ Hosp, Dept Cardiol, DK-5000 Odense, Denmark Odense Univ Hosp Odense Denmark DK-5000 Cardiol, DK-5000 Odense, Denmark
Titolo Testata:
JOURNAL OF DIABETES AND ITS COMPLICATIONS
fascicolo: 1, volume: 14, anno: 2000,
pagine: 7 - 12
SICI:
1056-8727(200001/02)14:1<7:ACANID>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIAC PARASYMPATHETIC ACTIVITY;
Keywords:
autonomic neuropathy; diabetes; function test; heart rate variability; methodology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: May, O Odense Univ Hosp, Dept Cardiol, DK-5000 Odense, Denmark Odense UnivHosp Odense Denmark DK-5000 , DK-5000 Odense, Denmark
Citazione:
O. May e H. Arildsen, "Assessing cardiovascular autonomic neuropathy in diabetes mellitus - How many tests to use?", J DIABET C, 14(1), 2000, pp. 7-12

Abstract

The aim was to evaluate the relative importance of an established battery of five function tests used in the assessment of cardiovascular autonomic neuropathy (CAN) in diabetes employing spectral analysis of heart rate variability (HRV) as the reference test. In a population-based sample of 178 diabetic persons and 194 non-diabetic controls, five function tests (E/I ratio, Valsalva, 30:15 ratio, Orthostatic-BP, and sustained Handgrip) and power spectral analysis of a 24-h Holter recording were carried out. The high-frequency power during nighttime (LnHF(NIGHT)) was taken to express the parasympathetic function and the daytime low-frequency power (LnLF(DAY)) to express the sympathetic function. The readings were log transformation when appropriate, age-corrected, and standardized to units of standard deviation. Combinations of the three mainly parasympathetic tests and the two mainly sympathetic tests were computed by averaging the standardized readings. A highvalue of the mean sum of squares in LnHFNIGHT or LnLF(DAY) - explained in regression analysis - was assumed to represent the better test or combination of tests. The three parasympathetic function tests each correlated significantly to LnHF(NIGHT) The E/I ratio had a correlation to LnHFNIGHT Similar to the combination of the three parasympathetic tests and the combinationof all dye function tests, whereas Valsalva and 30:15 ratio had a significantly poorer association. Sustained Handgrip-correlated significantly poorer to LnLF(DAY) compared to Orthostatic BP and the combination of the two sympathetic tests explained a significantly smaller part of the variation in LnLFDAY and LnHF(NIGHT) than did the combination of all five tests. This study indicates that: (1) no information is gained by adding the sympathetic function tests to the parasympathetic tests, (2) the most informative test is the E/I ratio, (3) and knowledge about the degree of CAN as defined by reduced HRV is not significantly increased when the four other function tests assessed are added to the E/I ratio. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 18:48:52