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Titolo:
Scavenger receptor class B type I (SR-BI) and high-density lipoprotein metabolism: Recent lessons from genetically manipulated mice
Autore:
Trigatti, B; Rigotti, A;
Indirizzi:
MIT, Dept Biol, Cambridge, MA 02139 USA MIT Cambridge MA USA 02139MIT, Dept Biol, Cambridge, MA 02139 USA Pontificia Univ Catolica Chile, Fac Med, Dept Gastroenterol, Santiago, Chile Pontificia Univ Catolica Chile Santiago Chile oenterol, Santiago, Chile
Titolo Testata:
INTERNATIONAL JOURNAL OF TISSUE REACTIONS-EXPERIMENTAL AND CLINICAL ASPECTS
fascicolo: 2-3, volume: 22, anno: 2000,
pagine: 29 - 37
SICI:
0250-0868(2000)22:2-3<29:SRCBTI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
APOPROTEIN-A-I; DIETARY-CHOLESTEROL; TARGETED MUTATION; APOLIPOPROTEIN-E; SELECTIVE UPTAKE; TRANSGENIC MICE; ADRENAL-CELLS; HUMAN HOMOLOG; HDL; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Rigotti, A MIT, Dept Biol, 77 Massachusetts Ave, Cambridge, MA 02139 USA MIT 77 Massachusetts Ave Cambridge MA USA 02139 e, MA 02139 USA
Citazione:
B. Trigatti e A. Rigotti, "Scavenger receptor class B type I (SR-BI) and high-density lipoprotein metabolism: Recent lessons from genetically manipulated mice", INT J TISS, 22(2-3), 2000, pp. 29-37

Abstract

The scavenger receptor BI is a cell surface lipoprotein receptor for selective high-density lipoprotein (HDL) cholesterol uptake in the liver and steroidogenic tissues. Studies of genetically manipulated strains of mice haverevealed that SR-BI plays a key role in regulating HDL metabolism, cholesterol transport to steroidogenic tissues and bile cholesterol secretion. Furthermore, SR-BI protects against the development of atherosclerosis and is required for normal female fertility: If SR-BI has similar functions in lipoprotein metabolism and atherosclerosis in humans, it may represent a new target for the prevention and/or treatment of atherosclerotic cardiovasculardisease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 20:59:39