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Titolo:
The distribution of cholinergic neurons in the human central nervous system
Autore:
Oda, Y; Nakanishi, I;
Indirizzi:
Kanazawa Univ, Fac Med, Dept Pathol 1, Kanazawa, Ishikawa 9208640, Japan Kanazawa Univ Kanazawa Ishikawa Japan 9208640 wa, Ishikawa 9208640, Japan
Titolo Testata:
HISTOLOGY AND HISTOPATHOLOGY
fascicolo: 3, volume: 15, anno: 2000,
pagine: 825 - 834
SICI:
0213-3911(200007)15:3<825:TDOCNI>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACETYLTRANSFERASE-IMMUNOREACTIVE NEURONS; HUMAN BASAL FOREBRAIN; HUMAN CEREBRAL-CORTEX; HUMAN STRIATUM; MESSENGER-RNA; SPINAL-CORD; HUMAN-BRAIN; ALZHEIMERS-DISEASE; NUCLEUS BASALIS; ACETYLCHOLINE INNERVATION;
Keywords:
choline acetyltransferase; central nervous system; human; immunohistochemistry; in situ hybridization;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Oda, Y Kanazawa Univ, Fac Med, Dept Pathol 1, 13-1 Takara Machi, Kanazawa,Ishikawa 9208640, Japan Kanazawa Univ 13-1 Takara Machi Kanazawa Ishikawa Japan 9208640 pan
Citazione:
Y. Oda e I. Nakanishi, "The distribution of cholinergic neurons in the human central nervous system", HIST HISTOP, 15(3), 2000, pp. 825-834

Abstract

Choline acetyltransferase (ChAT), the enzyme responsible for the biosynthesis of acetylcholine, is presently the most specific marker for identifyingcholinergic neurons in the central and peripheral nervous systems. The present article reviews immunohistochemical and in situ hybridization studies on the distribution of neurons expressing ChAT in the human central nervoussystem. Neurons with both immunoreactivity and in situ hybridization signals of ChAT are observed in the basal forebrain (diagonal band of Broca and nucleus basalis of Meynert), striatum (caudate nucleus, putamen and nucleusaccumbens), cerebral cortex, mesopontine tegmental nuclei (pedunculopontine tegmental nucleus, laterodorsal tegmental nucleus and parabigeminal nucleus), cranial motor nuclei and spinal motor neurons. The cerebral cortex displays regional and laminal differences in the distribution of neurons with ChAT. The medial septal nucleus and medial habenular nucleus contain immunoreactive neurons for ChAT, which are devoid of ChAT mRNA signals. This is probably because there is a small number of cholinergic neurons with a low level of ChAT gene expression in these nuclei of human. Possible connectionsand speculated functions of these neurons are briefly summarized.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 13:59:02