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Titolo:
Evaluation of the smooth muscle cell component and apoptosis in the varicose vein wall
Autore:
Bujan, J; Jimenez-Cossio, JA; Jurado, F; Gimeno, MJ; Pascual, G; Garcia-Honduvilla, N; Dominguez, B; Bellon, JM;
Indirizzi:
Univ Alcala, Fac Med, Dept Ciencias Morfol & Cirugia, Surg Res Lab, Madrid28871, Spain Univ Alcala Madrid Spain 28871 Cirugia, Surg Res Lab, Madrid28871, Spain Hosp La Paz, Serv Vasc Surg, Madrid, Spain Hosp La Paz Madrid SpainHosp La Paz, Serv Vasc Surg, Madrid, Spain
Titolo Testata:
HISTOLOGY AND HISTOPATHOLOGY
fascicolo: 3, volume: 15, anno: 2000,
pagine: 745 - 752
SICI:
0213-3911(200007)15:3<745:EOTSMC>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATHEROSCLEROTIC PLAQUES; SAPHENOUS VEINS; FRAGMENTED DNA; DEATH; ENDOTHELIUM; ETIOLOGY; COLLAGEN; HYPOXIA; ELASTIN; TUNEL;
Keywords:
varicose vein; smooth muscle cell; apoptosis; vein wall; proliferation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Bujan, J Univ Alcala, Fac Med, Dept Ciencias Morfol & Cirugia, Surg Res Lab, Ctra Madrid Barcelona,Km 33-6, Madrid 28871, Spain Univ Alcala Ctra Madrid Barcelona,Km 33-6 Madrid Spain 28871 ain
Citazione:
J. Bujan et al., "Evaluation of the smooth muscle cell component and apoptosis in the varicose vein wall", HIST HISTOP, 15(3), 2000, pp. 745-752

Abstract

This study was designed to evaluate the role of the smooth muscle cell andthe apoptosis in the pathogenesis of the varicose vein. Segments of saphenous vein were obtained from healthy subjects and from those with varicose veins. The vein specimens were subdivided according to subject age (younger or older than 50 years) and according to the varicose vein source (distal or proximal). Morphological, ultrastructural, eel proliferation (anti-PCNA method) and cell death (TUNEL method) analysis were performed. The walls of healthy, control vein specimens acquired a more collagenous and papilomatous appearance with age. A slight increase in the number of TUNEL-positive cells was also observed in specimens from older subjects. The proportion of apoptotic cells was much greater in the varicose veins than incontrol specimens. Most cellular alterations were seen in proximal varicose segments obtained from young subjects. These specimens showed hypertrophic areas with a high degree of cellularity (both in the media and in the thickened intima). The highest proportion of apoptotic cells and collagenisation were also observed in these areas. The enhanced number of apoptotic cells in varicose veins observed mainly in proximal/young vein specimens could be responsible, at least in part, for the acceleration of the final fibrosclerotic process characteristic of the varicose vein wall.

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Documento generato il 13/07/20 alle ore 08:03:54